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Elesclomol

(Synonyms: STA-4783)
130 Cited Publications
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Based on 130 publication(s) in Google Scholar

Elesclomol (STA-4783) is a potent copper ionophore and promotes copper-dependent cell death (cuproptosis). Elesclomol specifically binds ferredoxin 1 (FDX1) α2/α3 helices and β5 strand. Elesclomol inhibits FDX1-mediated Fe-S cluster biosynthesis. Elesclomol is an oxidative stress inducer that induces cancer cell apoptosis. Elesclomol is a reactive oxygen species (ROS) inducer. Elesclomol can be used for Menkes and associated disorders of hereditary copper deficiency research.

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  • Purity: 99.19%
  • CAS No.: 488832-69-5
  • 화학식: C19H20N4O2S2
  • 분자량:400.52
  • 보관:
    Powder   -20°C, 3 years , 4°C, 2 years ; In solvent   -80°C, 1 year , -20°C, 6 months
  • Elesclomol Chemical Structure
    Elesclomol Chemical Structure
  • Experimental Validation Results for Elesclomol
  • Experimental Validation Results for Elesclomol
  • Experimental Validation Results for Elesclomol
  • Experimental Validation Results for Elesclomol
CAS No.: 488832-69-5
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  • Elesclomol Chemical Structure
    Elesclomol Chemical Structure
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  • 1/16

    Elesclomol purchased from MedChemExpress. Usage Cited in: J Hazard Mater. 2024 Jul 31:477:135391. [Abstract]

    Customer Validation
     Elesclomol (20-80 nM; 6-24 h) with copper (ES/Cu) promotes cell death in a dose-dependent manner and cell growth in GCs.
    (b) Cell viability of ovarian granulosa cells under concentration gradients of 3-NP, Cu and ES, with a dashed line indicating the inhibition rate of 50% (IC50); (e) The survival ratio of mGCs treated with 40nM ES or 10μM TTM and exposed to a copper concentration gradient was assessed by CCK-8 assay.

  • 1/16

    Elesclomol purchased from MedChemExpress. Usage Cited in: Nat Chem Biol. 2019 Jul;15(7):681-689. [Abstract]

    Customer Validation
     The viability of 724 barcoded cell lines was determined for 8 concentrations of elesclomol and the calculated area under the curve (AUC) is presented as box plot for different lineages.
    Elesclomol is very potent in inducing cell death across all lineages with most cells showing sensitivity at doses above 100nM.

  • 1/16

    Elesclomol purchased from MedChemExpress. Usage Cited in: Nat Chem Biol. 2019 Jul;15(7):681-689. [Abstract]

    Customer Validation
     The viability of T47D cells cultured in the presence of galactose (Hi-Mito state) was examined following the addition of either elesclomol in the presence or absence of the copper chelator tetrathiomolybdate (TTM) at 10uM concentration.

  • 1/16

    Elesclomol purchased from MedChemExpress. Usage Cited in: Biomolecules. 2019 Jul 24;9(8):298. [Abstract]

    Customer Validation
     Confocal images of MitoSOX fluorescence intensity in CV-1 cells at the 20-min time point after E:C (elesclomol:copper)- treatment in the presence and absence of the mitochondrial superoxide scavenger MitoTEMPO.

  • Elesclomol