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PF-573228

39 Cited Publications
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Based on 39 publication(s) in Google Scholar

PF-573228 is a potent and selective FAK inhibitor with IC50 of 4 nM for purified recombinant catalytic fragment of FAK.

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  • Purity: 99.32%
  • CAS No.: 869288-64-2
  • 화학식: C22H20F3N5O3S
  • 분자량:491.49
  • 보관:
    Powder   -20°C, 3 years , 4°C, 2 years ; In solvent   -80°C, 2 years , -20°C, 1 year
  • PF-573228 Chemical Structure
    PF-573228 Chemical Structure
  • Experimental Validation Results for PF-573228
  • Experimental Validation Results for PF-573228
  • Experimental Validation Results for PF-573228
CAS No.: 869288-64-2
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  • PF-573228 Chemical Structure
    PF-573228 Chemical Structure
    1/16
  • 1/16

    PF-573228 purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2020 Jun 17;7(15):1903583. [Abstract]

    Customer Validation
     Fluorescence imaging of LNCaP cells treated with the F-actin inhibitor cytoskeleton B (CB), microtubule inhibitor nocodazole (NO), FAK inhibitor PF573288 (PF), ROCK inhibitor Y-27632 (Y), and myosin II (Myo-II) inhibitor (-)-blebbistatin ((-)Bl). After the cells were cultured on different substrates for 3 days, inhibitors were added and incubated for 24 h. (green, F-actin; scale bar, 25 µm).

  • 1/16

    PF-573228 purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2020 Jun 17;7(15):1903583. [Abstract]

    Customer Validation
     Expression of CTC cluster-related (plakoglobin and CD44) and EMT-related (vimentin and E-cadherin, 4 days) proteins in LNCaP cells grown on different substrates after treatment with different inhibitors (Cytoskeleton B (CB), Nocodazole (NO), PF-573288 (PF), Y-27632 (Y), and (-)-Blebbistatin ((-) Bl)).

  • 1/16

    PF-573228 purchased from MedChemExpress. Usage Cited in: Cell Adh Migr. 2017 Jul 4;11(4):327-337. [Abstract]

    Customer Validation
     BAC1.2F5 cells are cultured in the absence of CSF-1 for 18 hours and then kept in suspension for 45 minutes and lysed (0) or plated on FN-coated dishes (10 mg/mL) for 30 minutes in the presence or the absence of PF-573228 (1 mM) before lysis. Proteins are subjected to immunoblotting with the indicated antibodies.

  • PF-573228