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A2AR modulator-1

A2AR modulator-1 (Compound 45) is a selective negative allosteric adenosine A2a receptor (A2aR) modulator with an IC50 value of 9 nM. A2AR modulator-1 reduces the affinity of endogenous adenosine for the receptor and inhibits cAMP signaling pathway activation. A2AR modulator-1 potently restores pCREB phosphorylation in CD4+ T cells, reversing immunosuppression in the tumor microenvironment, and shows potential to suppress tumor growth and metastasis in triple-negative breast cancer models.

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  • CAS No.: 3007566-23-3
  • 화학식: C23H20N6
  • 분자량:380.45
  • 보관:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • A2AR modulator-1 Chemical Structure
    A2AR modulator-1 Chemical Structure
CAS No.: 3007566-23-3
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  • A2AR modulator-1