Alloxazine
Based on 1 Customer Validation
Alloxazine is a selective A2b antagonist. Alloxazine completely block 5’N-Ethylcarboxamido adenosine (NECA)-mediated cyclic AMP accumulation with an IC50 of 2.9 μM. Alloxazine can be used for the research of cancer.
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- Purity: 99.46%
- CAS No.: 490-59-5
- 화학식: C10H6N4O2
- 분자량:214.18
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보관:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
- References
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All Adenosine Receptor Isoforms
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Biological Activity
IC50: 2.9 μM (AMP)[1]
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| NIH3T3 | IC50 |
>50 μM
Compound: 62
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Inhibitory activity against platelet-derived growth factor receptor tyrosine kinase in Swiss 3T3 cells
Inhibitory activity against platelet-derived growth factor receptor tyrosine kinase in Swiss 3T3 cells
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[PMID: 8667360] |
Alloxazine (0-30 μM, 20 min) inhibits cyclic AMP production in PGT-β cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:PGT-β cells
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Concentration:0-30 μM
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Incubation Time:20 min
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Result:Inhibited the cyclic AMP generation concentration-dependently with an IC50 of 2.9 μM.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male Sprague-Dawley rats[2]
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Dosage:1 µmol/L
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Administration:Cortical surface suffusion; 1 µmol/L once
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Result:Significantly suppressed vasodilation with increased EC25 value of 0.60 µmol/L.
Chemical Information
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CAS No. 490-59-5
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Appearance Solid
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분자량 214.18
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화학식 C10H6N4O2
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Color Light yellow to yellow
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SMILES
O=C(N1)N=C2NC3=CC=CC=C3N=C2C1=O
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Synonyms
Isoalloxazine
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
용액&용해도
DMSO : 5 mg/mL (23.34 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
순도&문서
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Data Sheet (275 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Brackett LE, Daly JW. Functional characterization of the A2b adenosine receptor in NIH 3T3 fibroblasts. Biochem Pharmacol. 1994 Mar 2;47(5):801-14. [Content Brief]
[2]. Shin HK, et al. Role of adenosine A(2B) receptors in vasodilation of rat pial artery and cerebral blood flow autoregulation. Am J Physiol Heart Circ Physiol. 2000 Feb;278(2):H339-44. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 4.6690 mL | 23.3449 mL | 46.6897 mL | 116.7243 mL |
| 5 mM | 0.9338 mL | 4.6690 mL | 9.3379 mL | 23.3449 mL | |
| 10 mM | 0.4669 mL | 2.3345 mL | 4.6690 mL | 11.6724 mL | |
| 15 mM | 0.3113 mL | 1.5563 mL | 3.1126 mL | 7.7816 mL | |
| 20 mM | 0.2334 mL | 1.1672 mL | 2.3345 mL | 5.8362 mL |
Alloxazine Related Classifications
HY-123085 Related Classifications
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