Amisulpride-d5
Based on 1 Customer Validation
Amisulpride-d5 is the deuterium labeled Amisulpride. Amisulpride is a dopamine D2/D3 receptor antagonist with Kis of 2.8 and 3.2 nM for human dopamine D2 and D3, respectively.
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- Purity: 98.27%
- CAS No.: 1216626-17-3
- 화학식: C17H22D5N3O4S
- 분자량:374.51
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보관:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
- References
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Help & FAQs
All Dopamine Receptor Isoforms
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Biological Activity
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D3 Receptor |
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 1216626-17-3
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Unlabeled Cas 71675-85-9
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Appearance Solid
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분자량 374.51
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화학식 C17H22D5N3O4S
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Color White to off-white
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SMILES
[2H]C([2H])([2H])C([2H])([2H])N(CCC1)C1CNC(C2=C(C=C(C(S(CC)(=O)=O)=C2)N)OC)=O
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Synonyms
(Rac)-Aramisulpride-d5; (Rac)-Esamisulpride-d5; DAN 2163-d5
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
용액&용해도
DMSO : 50 mg/mL (133.51 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : 0.2 mg/mL (0.53 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
순도&문서
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Data Sheet (274 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
[2]. Schoemaker H, et al. Neurochemical characteristics of amisulpride, an atypical dopamine D2/D3 receptor antagonist with both presynaptic and limbic selectivity. J Pharmacol Exp Ther. 1997 Jan;280(1):83-97. [Content Brief]
[3]. Pawar GR, et al. Evaluation of antidepressant like property of amisulpride per se and its comparison with fluoxetine and olanzapine using forced swimming test in albino mice. Acta Pol Pharm. 2009 May-Jun;66(3):327-31. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 2.6702 mL | 13.3508 mL | 26.7016 mL | 66.7539 mL |
| 5 mM | 0.5340 mL | 2.6702 mL | 5.3403 mL | 13.3508 mL | |
| 10 mM | 0.2670 mL | 1.3351 mL | 2.6702 mL | 6.6754 mL | |
| 15 mM | 0.1780 mL | 0.8901 mL | 1.7801 mL | 4.4503 mL | |
| 20 mM | 0.1335 mL | 0.6675 mL | 1.3351 mL | 3.3377 mL | |
| 25 mM | 0.1068 mL | 0.5340 mL | 1.0681 mL | 2.6702 mL | |
| 30 mM | 0.0890 mL | 0.4450 mL | 0.8901 mL | 2.2251 mL | |
| 40 mM | 0.0668 mL | 0.3338 mL | 0.6675 mL | 1.6688 mL | |
| 50 mM | 0.0534 mL | 0.2670 mL | 0.5340 mL | 1.3351 mL | |
| 60 mM | 0.0445 mL | 0.2225 mL | 0.4450 mL | 1.1126 mL | |
| 80 mM | 0.0334 mL | 0.1669 mL | 0.3338 mL | 0.8344 mL | |
| 100 mM | 0.0267 mL | 0.1335 mL | 0.2670 mL | 0.6675 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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