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Cat. No.: HY-187926

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Antimalarial agent 67

Antimalarial agent 67 is an orally active inositol acyltransferase Gwt1p inhibitor and antimalarial agent, with IC₅₀ values of 0.030 μM and 0.041 μM against P. falciparum 3D7 and K1 strains, respectively. Antimalarial agent 67 blocks inositol ring acylation by inhibiting the key enzyme Gwt1p in the GPI biosynthesis pathway of Plasmodium, thereby inhibiting parasite growth and maturation. Antimalarial agent 67 can be used for research on malaria.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

CAS No.: 2675491-09-3
화학식: C₂₁H₁₉F₆N₇O₂
분자량:515.42

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Antimalarial agent 67 Chemical Structure

CAS No.: 2675491-09-3

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- In Vitro
- In Vivo
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

All Parasite Isoforms :

All Acyltransferase Isoforms :

In Vitro

Parasitic Infection

Antimalarial agent 67 (compound VII) (0.001-1 μg/mL; 72 h) exhibits antimalarial activity against the erythrocytic stages of P. falciparum 3D7 and K1 strains in vitro, with IC₅₀ values of 0.030 μM and 0.041 μM, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Parasitic Infection

Antimalarial agent 67 (Compound VII) (10 mL/kg; p.o.; once daily; for 3 consecutive days) exhibits antimalarial activity in a humanized immunodeficient NSG mouse model engrafted with human erythrocytes and infected with P. falciparum (Pf3D70087/N9)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

NSG (NOD-scid IL-2RYnull) mice (female) were infected with P. falciparum (Pf3D70087/N9)^[1]
Dosage:

10 mL/kg
Administration:

p.o.; once daily; for 3 consecutive days
Result:

Demonstrated in vivo antimalarial efficacy, being able to significantly reduce parasitemia in peripheral blood. The daily dose that reduced parasitemia by 90% compared to untreated control animals at day seven post-infection (ED90) was 6.2 mg/kg/day.

Chemical Information

CAS No. 2675491-09-3
분자량 515.42
화학식 C₂₁H₁₉F₆N₇O₂
SMILES

O=C(NCC1=CC=C(OCC(F)(F)F)C=C1)C=2C=C(C(=NC2N)N)N3N=C(N=C3)C4(CC4)C(F)(F)F
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Takaaki Horii, et al. Novel antimalarial agent containing heterocyclic compound. WO2021149692A1. WIPO. 2021-07-29.

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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Amount: USD 0.00

Biological Activity
- 제품 설명
- In Vitro
- In Vivo
Chemical Information
순도&문서
References

상품명:
Cat. No.:
수량:
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상품명:
CAS No.:
Species:
Purity:
수량:

Antimalarial agent 67

All Parasite Isoforms

All Acyltransferase Isoforms