APG808
Based on 1 Customer Validation
APG808 (PR001) is an anti-human IL-4Rα monoclonal antibody. APG808 binds to IL-4Rα, prevents IL-13Rα1/IL-4Rα heterodimer formation, and disrupts IL-13 and IL-4 mediated signaling. APG808 ablates Fc and complement effector functions. APG808 can be used for the research of chronic obstructive pulmonary disease, asthma, atopic dermatitis.
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
- Purity: 97.02%
- 분자량:142.63 kDa
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
Biological Activity
Human IgG1 kappa
Human
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IL-4Rα/IL4R/CD124 |
APG808 has a high affinity for human FcRn at pH 6.0, reduced affinity for human FcγRI, FcγRIIIa (F158), and FcγRIIIa (V158), and no detectable binding to human FcγRIIa (H131), FcγRIIa (R131), FcγRIIIb, or C1q[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| Species | Dose | Route | AUC0-inf | CL | Vss | Bioavailability | T1/2 |
|---|---|---|---|---|---|---|---|
| Cynomolgus Monkey[1] | 25.9 mg/kg | s.c. | 9.77 × 106 ng·h/mL | 2.79 | 101.80 mL/kg | 97.51 % | 27.18 |
IL-4Ra/CD124
Unconjugated
The product can be reconstituted/diluted with sterile PBS or saline.
ELISA, FACS, Functional assay
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Immobilized IL-4R alpha/CD124 Protein, Human (HEK293, HY-P70710) can bind APG808. The ED50 for this effect is 59.8 ng/mL.
Chemical Information
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Appearance Liquid
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분자량 142.63 kDa
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Color Colorless to light yellow
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SMILES
[APG808]
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Synonyms
PR001
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선적
Shipping with dry ice.
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
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Data Sheet (281 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Inhibitory Antibodies User Guide (603 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
APG808 Related Classifications
HY-P992034 Related Classifications
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