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Astegolimab

(Synonyms: MSTT 1041A; RG 6149)
3 Cited Publications
고객리뷰

Based on 3 publication(s) in Google Scholar

Astegolimab (MSTT 1041A; RG 6149) is a human IgG2 monoclonal antibody. Astegolimab blocks IL-33 signaling by targeting the IL-33 receptor ST2. Astegolimab reduces p53 expression, mitigates IL33-upregulated SASP factors such as IL1α, IL6 and MCP1. Astegolimab mitigates IL33-increased p-p65/p65 ratio. Astegolimab blocks CM-induced neutrophil extracellular trap (NET) formation. Astegolimab is used in chronic obstructive pulmonary disease (COPD) and myocardial research.

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  • Experimental Validation Results for Astegolimab
  • Experimental Validation Results for Astegolimab
  • Experimental Validation Results for Astegolimab
  • Experimental Validation Results for Astegolimab
  • Experimental Validation Results for Astegolimab
  • Astegolimab Chemical Structure
    Astegolimab Chemical Structure
CAS No.: 2173054-79-8
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Assay Types
  • 1/16

    Human IgG2 kappa

  • 1/16

    Immobilized ST2/IL1RL1 Protein, Human can bind Astegolimab. The EC50 for this effect is 28.29 ng/mL.

  • 1/16

    Loaded ST2/IL1RL1 Protein, Human (310a.a, HEK293, His, HY-P70615) on AHC2 biosensor, can bind Astegolimab with an affinity constant of 2.022E-10 M as determined in BLI assay.

  • 1/16

    Astegolimab purchased from MedChemExpress. Usage Cited in: Cell Oncol (Dordr). 2025 Apr;48(2):487-504. [Abstract]

    Customer Validation
     Astegolimab (IL33-IN). ELISA was used to detect the concentrations of mouse bone marrow-derived ribonuclease (BMDN) and elastase in HL-60 cell supernatant.

  • 1/16

    Astegolimab purchased from MedChemExpress. Usage Cited in: Cell Oncol (Dordr). 2025 Apr;48(2):487-504. [Abstract]

    Customer Validation
     Astegolimab (IL33-IN). Western blot analysis of molecules associated with NET formation in mouse bone marrow-derived macrophages (BMDN).

  • Astegolimab Chemical Structure
    1/16
  • Astegolimab
  • Immobilized ST2/IL1RL1 Protein, Human can bind Astegolimab. The EC50 for this effect is 28.29 ng/mL.
  • Loaded ST2/IL1RL1 Protein, Human (310a.a, HEK293, His, HY-P70615) on AHC2 biosensor, can bind Astegolimab with an affinity constant of 2.022E-10 M as determined in BLI assay.