BAPTA tetracesium
Based on 36 publication(s) in Google Scholar
BAPTA tetracesium is a selective and cell-impermeant chelator for calcium. BAPTA tetracesium has high selectivity against magnesium and calcium. BAPTA tetracesium can also inhibit phospholipase C activity independently of their role as Ca2+ chelators.
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- CAS No.: 480436-84-8
- 화학식: C22H20Cs4N2O10
- 분자량:1004.02
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Publications Citing Use of MedChemExpress (MCE) BAPTA tetracesium
More- Mil Med Res. 2023 Nov 25;10(1):56. [Abstract]
- Sci Immunol. 2019 Jun 28;4(36):eaau6426. [Abstract]
- Adv Sci (Weinh). 2021 Aug;8(15):e2100363. [Abstract]
- J Clin Invest. 2024 Apr 25;134(12):e176355. [Abstract]
- J Neuroinflammation. 2025 Aug 28;22(1):208. [Abstract]
- Environ Chem Ecotoxicol. 2025 Nov 19;8:267-280.
- Free Radic Biol Med. 2024 Mar:213:150-163. [Abstract]
- Sci Total Environ. 2020 Feb 10;703:134702. [Abstract]
- Biomed Pharmacother. 2023 Oct:166:115343. [Abstract]
- Biomed Pharmacother. 2023 May:161:114480. [Abstract]
- Cell Death Discov. 2026 May 25.
- Cell Rep. 2025 Dec 10;44(12):116673. [Abstract]
- J Pineal Res. 2024 Aug;76(5):e12987. [Abstract]
- J Invest Dermatol. 2024 May 30:S0022-202X(24)00384-1. [Abstract]
- J Ginseng Res. 2022 Jul;46(4):515-525. [Abstract]
- J Ethnopharmacol. 2025 Apr 29:348:119863. [Abstract]
- J Ethnopharmacol. 2023 Feb 10;302(Pt A):115923. [Abstract]
- Int J Pharm. 2025 Nov 10:684:126125. [Abstract]
- J Thromb Haemost. 2021 Dec;19(12):3113-3125. [Abstract]
- Int J Mol Sci. 2026 Jan 1;27(1):468. [Abstract]
- Int Immunopharmacol. 2026 Mar 1:172:116168. [Abstract]
- Toxicology. 2023 Dec:500:153674. [Abstract]
- Biochim Biophys Acta Mol Basis Dis. 2025 Jul 18;1871(8):167990. [Abstract]
- Exp Neurol. 2023 May:363:114350. [Abstract]
- J Cell Mol Med. 2020 Aug;24(16):9287-9299. [Abstract]
- J Funct Foods. 2024 Oct.
- J Funct Foods. December 2021, 104791.
- Aging. 2019 Nov 22;11(22):10385-10408. [Abstract]
- Mol Med Rep. 2024 Jan;29(1):13. [Abstract]
- Cardiovasc Ther. 2023 Mar 30:2023:3939360. [Abstract]
- J Pharm Pharmacol. 2024 May 3;76(5):567-578. [Abstract]
- J Cancer. 2024 Jan 1;15(2):343-355. [Abstract]
- Vet Microbiol. 2019 Dec;239:108498. [Abstract]
- Toxicon. 2026 Jun 15:276:109072. [Abstract]
- Res Sq. 2025 Apr 18.
- bioRxiv. 2023 Jun 25.
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BAPTA tetracesium is widely used as an intracellular buffer to investigate the effects caused by Ca2+ release from intracellular calcium stores or Ca2+ influx via Ca2+-permeable channels in the plasma membrane[1].
BAPTA tetracesium can be introduced into cells via methods such as patch-clamp and microinjection[1].
BAPTA tetracesium inhibits PLC activity in isolated Drosophila melanogaster photoreceptor cells with an IC50 of approximately 8 mM[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 480436-84-8
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분자량 1004.02
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화학식 C22H20Cs4N2O10
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SMILES
O=C(O[Cs])CN(CC(O[Cs])=O)C1=C(OCCOC2=C(N(CC(O[Cs])=O)CC(O[Cs])=O)C=CC=C2)C=CC=C1
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (36)
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Journal Impact Factor
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Most Recent
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Mil Med Res
Targeting GPR65 alleviates hepatic inflammation and fibrosis by suppressing the JNK and NF-κB pathways. [Abstract]2023 Nov 25;10(1):56. PMID: 38001521
BAPTA tetracesium purchased from MedChemExpress. Usage Cited in: Mil Med Res. 2023 Nov 25;10(1):56. [Abstract]
BAPTA (10 μmol/L, 24 h). qRT-PCR was used to assess the mRNA level of Il6, Tnfα and Tgfβ3 in HMs.
BAPTA tetracesium purchased from MedChemExpress. Usage Cited in: Mil Med Res. 2023 Nov 25;10(1):56. [Abstract]
BAPTA (10 μmol/L, 24 h). TGF-β1 and IL-6 level in the supernatant of HMs were detected by ELISA.
BAPTA tetracesium purchased from MedChemExpress. Usage Cited in: Mil Med Res. 2023 Nov 25;10(1):56. [Abstract]
BAPTA (10 μmol/L, 24 h). The expression and location of TNF-α in HMs was assessed by confocal microscopy (c). Scale bar = 20 μm.
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Sci Immunol
2019 Jun 28;4(36):eaau6426. PMID: 31253642 -
Adv Sci (Weinh)
2021 Aug;8(15):e2100363. PMID: 34047068 -
J Clin Invest
Chromosomal 3q amplicon encodes essential regulators of secretory vesicles that drive secretory addiction in cancer. [Abstract]2024 Apr 25;134(12):e176355. PMID: 38662435 -
J Neuroinflammation
P2X7-CaMKII drives 5-LOX nuclear translocation to impair microglial function after subarachnoid hemorrhage. [Abstract]2025 Aug 28;22(1):208. PMID: 40877894
BAPTA tetracesium purchased from MedChemExpress. Usage Cited in: J Neuroinflammation. 2025 Aug 28;22(1):208. [Abstract]
BAPTA (10 μM). WB results showed that BAPTA could attenuate the Hb-induced decrease in LAMP1 and m-CTSD/pro-CTSD.
BAPTA tetracesium purchased from MedChemExpress. Usage Cited in: J Neuroinflammation. 2025 Aug 28;22(1):208. [Abstract]
IF results showed that BAPTA (10 μM) can partially increase the co-localization coefficients of LAMP1 and CTSD.
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Free Radic Biol Med
Quercetin induces ferroptosis in gastric cancer cells by targeting SLC1A5 and regulating the p-Camk2/p-DRP1 and NRF2/GPX4 Axes. [Abstract]2024 Mar:213:150-163. PMID: 38190923 -
Sci Total Environ
Microcystin-leucine-arginine induced neurotoxicity by initiating mitochondrial fission in hippocampal neurons. [Abstract]2020 Feb 10;703:134702. PMID: 31753492 -
Biomed Pharmacother
Barasertib impedes chondrocyte senescence and alleviates osteoarthritis by mitigating the destabilization of heterochromatin induced by AURKB. [Abstract]2023 Oct:166:115343. PMID: 37634474 -
Biomed Pharmacother
Interruption of TRPC6-NFATC1 signaling inhibits NADPH oxidase 4 and VSMCs phenotypic switch in intracranial aneurysm. [Abstract]2023 May:161:114480. PMID: 37002575 -
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Cell Rep
Aryl hydrocarbon receptor-induced activation of AIM2 inflammasome is mediated by MOMP and MPT: A vital therapeutic pathway for inflammation. [Abstract]2025 Dec 10;44(12):116673. PMID: 41385364 -
J Pineal Res
2024 Aug;76(5):e12987. PMID: 38975671 -
J Invest Dermatol
TRPV3-Activated PARP1/AIFM1/MIF Axis through Oxidative Stress Contributes to Atopic Dermatitis. [Abstract]2024 May 30:S0022-202X(24)00384-1. PMID: 38823435 -
J Ginseng Res
Ginsenoside Rg1 attenuates cerebral ischemia-reperfusion injury due to inhibition of NOX2-mediated calcium homeostasis dysregulation in mice. [Abstract]2022 Jul;46(4):515-525. PMID: 35818419 -
J Ethnopharmacol
Ginsenoside Rg1 attenuates T2DM-induced renal damage and fibrosis by inhibiting TRPC6-ChREBP-TXNIP signaling. [Abstract]2025 Apr 29:348:119863. PMID: 40311716 -
J Ethnopharmacol
Ginsenoside Rg1 attenuates glomerular fibrosis by inhibiting CD36/TRPC6/NFAT2 signaling in type 2 diabetes mellitus mice. [Abstract]2023 Feb 10;302(Pt A):115923. PMID: 36375645 -
Int J Pharm
Reversible increased basement membrane permeability and calcium ion redistribution facilitate ultrasound-enhanced transdermal drug delivery efficiency. [Abstract]2025 Nov 10:684:126125. PMID: 40914558 -
J Thromb Haemost
2021 Dec;19(12):3113-3125. PMID: 34411418 -
Int J Mol Sci
Gut Microbiota-Derived Propionic Acid Mediates ApoA-I-Induced Amelioration of MASLD via Activation of GPR43-Ca2+-CAMKII-ATGL Hepatic Lipolysis. [Abstract]2026 Jan 1;27(1):468. PMID: 41516340 -
Int Immunopharmacol
Piezo1 activates Wnt5a/FZD4 signaling to promote osteogenesis and mitigates age-associated bone loss. [Abstract]2026 Mar 1:172:116168. PMID: 41529412 -
Toxicology
Nonivamide inhibits proliferation of human corneal epithelial cells by inducing cell cycle arrest and oxidative stress. [Abstract]2023 Dec:500:153674. PMID: 37989449 -
Biochim Biophys Acta Mol Basis Dis
Activation of IRF2 signaling networks facilitates podocyte pyroptosis in lupus nephritis. [Abstract]2025 Jul 18;1871(8):167990. PMID: 40684959 -
Exp Neurol
Trpc6 knockout improves behavioral dysfunction and reduces Aβ production by inhibiting CN-NFAT1 signaling in T2DM mice. [Abstract]2023 May:363:114350. PMID: 36791875 -
J Cell Mol Med
Calpain-2 plays a pivotal role in the inhibitory effects of propofol against TNF-α-induced autophagy in mouse hippocampal neurons. [Abstract]2020 Aug;24(16):9287-9299. PMID: 32627970 -
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Aging
Rotating magnetic field delays human umbilical vein endothelial cell aging and prolongs the lifespan of Caenorhabditis elegans. [Abstract]2019 Nov 22;11(22):10385-10408. PMID: 31757933 -
Mol Med Rep
Trpc6 knockout protects against renal fibrosis by restraining the CN‑NFAT2 signaling pathway in T2DM mice. [Abstract]2024 Jan;29(1):13. PMID: 38038121 -
Cardiovasc Ther
KCa3.1 Promotes Proinflammatory Exosome Secretion by Activating AKT/Rab27a in Atrial Myocytes during Rapid Pacing. [Abstract]2023 Mar 30:2023:3939360. PMID: 37035755 -
J Pharm Pharmacol
2024 May 3;76(5):567-578. PMID: 38271051 -
J Cancer
JS-K activates G2/M checkpoints through the DNA damage response and induces autophagy via CAMKKβ/AMPKα/mTOR pathway in bladder cancer cells. [Abstract]2024 Jan 1;15(2):343-355. PMID: 38169515 -
Vet Microbiol
S100A9 regulates porcine reproductive and respiratory syndrome virus replication by interacting with the viral nucleocapsid protein. [Abstract]2019 Dec;239:108498. PMID: 31767072 -
Toxicon
Transient receptor potential canonical 6 is critical for chronic lipopolysaccharide exposure-induced pulmonary injury and fibrosis. [Abstract]2026 Jun 15:276:109072. PMID: 41850440 -
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순도&문서
References
[1]. Tsien RY, et al. New calcium indicators and buffers with high selectivity against magnesium and protons: design, synthesis, and properties of prototype structures. Biochemistry. 1980;19(11):2396-2404. [Content Brief]
[2]. Hardie RC. Inhibition of phospholipase C activity in Drosophila photoreceptors by 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid (BAPTA) and di-bromo BAPTA. Cell Calcium. 2005 Dec;38(6):547-56. [Content Brief]
[3]. Collatz MB, et al. Intracellular calcium chelator BAPTA protects cells against toxic calcium overload but also alters physiological calcium responses. Cell Calcium. 1997;21(6):453-459. [Content Brief]
Calculators
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