Benzenesulphonamide
Based on 1 Customer Validation
Benzenesulphonamide (Compound 1) is a carbonic anhydrase inhibitor. Benzenesulphonamide exhibits CA II inhibitory activity. Benzenesulphonamide reduces ROS and improves the gene expression of amyloid-β40 and 42. Benzenesulphonamide is beneficial for Alzheimer's disease. Benzenesulphonamide derivatives have anticancer, anti-inflammatory, and anticonvulsant activities. Benzenesulphonamide can be used in the research of Alzheimer's disease, epilepsy, inflammatory diseases, leukemia, melanoma, lung cancer, and colon cancer.
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- Purity: 99.75%
- CAS No.: 98-10-2
- 화학식: C6H7NO2S
- 분자량:157.19
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보관:
Store at room temperature 3 years.
In solvent -80°C, 2 years , -20°C, 1 year
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
- References
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Help & FAQs
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Biological Activity
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CA Ⅱ |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 98-10-2
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Appearance Solid
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분자량 157.19
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화학식 C6H7NO2S
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Color White to off-white
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SMILES
O=S(C1=CC=CC=C1)(N)=O
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Store at room temperature 3 years
In solvent -80°C 2 years -20°C 1 year
용액&용해도
DMSO : 100 mg/mL (636.17 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
순도&문서
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Data Sheet (276 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Thakur A, et al. QSAR study on benzenesulphonamide carbonic anhydrase inhibitors: topological approach using Balaban index. Bioorg Med Chem. 2004 Feb 15;12(4):789-93. [Content Brief]
[2]. Hesar Shourkabi M, et al. Benzenesulfonamide as a novel, pharmaceutical small molecule inhibitor on Aβ gene expression and oxidative stress in Alzheimer's Wistar rats. Biochem Biophys Res Commun. 2023 Sep 24;674:154-161. [Content Brief]
[3]. Bashir R, et al. Synthesis of some new 1,3,5-trisubstituted pyrazolines bearing benzene sulfonamide as anticancer and anti-inflammatory agents. Bioorg Med Chem Lett. 2011 Jul 15;21(14):4301-5. [Content Brief]
[4]. Nissan YM, et al. New benzenesulfonamide scaffold-based cytotoxic agents: Design, synthesis, cell viability, apoptotic activity and radioactive tracing studies. Bioorg Chem. 2020 Mar;96:103577. [Content Brief]
[5]. Wang Z, et al. Synthesis and Pharmacological Evaluation of Novel Benzenesulfonamide Derivatives as Potential Anticonvulsant Agents. Molecules. 2015 Sep 23;20(9):17585-600. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 6.3617 mL | 31.8086 mL | 63.6173 mL | 159.0432 mL |
| 5 mM | 1.2723 mL | 6.3617 mL | 12.7235 mL | 31.8086 mL | |
| 10 mM | 0.6362 mL | 3.1809 mL | 6.3617 mL | 15.9043 mL | |
| 15 mM | 0.4241 mL | 2.1206 mL | 4.2412 mL | 10.6029 mL | |
| 20 mM | 0.3181 mL | 1.5904 mL | 3.1809 mL | 7.9522 mL | |
| 25 mM | 0.2545 mL | 1.2723 mL | 2.5447 mL | 6.3617 mL | |
| 30 mM | 0.2121 mL | 1.0603 mL | 2.1206 mL | 5.3014 mL | |
| 40 mM | 0.1590 mL | 0.7952 mL | 1.5904 mL | 3.9761 mL | |
| 50 mM | 0.1272 mL | 0.6362 mL | 1.2723 mL | 3.1809 mL | |
| 60 mM | 0.1060 mL | 0.5301 mL | 1.0603 mL | 2.6507 mL | |
| 80 mM | 0.0795 mL | 0.3976 mL | 0.7952 mL | 1.9880 mL | |
| 100 mM | 0.0636 mL | 0.3181 mL | 0.6362 mL | 1.5904 mL |
Benzenesulphonamide Related Classifications
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