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Cat. No.: HY-179463

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BKI 1708

BKI 1708 is a potent and orally active calcium-dependent protein kinase 1 (CDPK1) inhibitor (IC₅₀ = 0.7 nM). BKI 1708 exhibits potent activity against Neospora (IC₅₀ = 481 nM) and Toxoplasma (IC₅₀ = 122 nM). BKI-1708 induces the formation of multinucleated complexes. BKI-1708 efficiently inhibits vertical transmission of both parasites and increases pup survival in mice.

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CAS No.: 2332840-70-5
화학식: C₂₂H₂₆N₄O₃
분자량:394.47

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (279 KB)

BKI 1708 Chemical Structure

CAS No.: 2332840-70-5

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

제품 설명

All Parasite Isoforms :

Chemical Information

CAS No. 2332840-70-5
분자량 394.47
화학식 C₂₂H₂₆N₄O₃
SMILES

O=C(C1=C(N)N(CC(C)(CO)C)N=C1C2=CC3=C(C=C(C=C3)OC4CC4)C=C2)N
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (279 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. de Sousa MCF, et al. Efficacy of the bumped kinase inhibitor BKI-1708 against the cyst-forming apicomplexan parasites Toxoplasma gondii and Neospora caninum in vitro and in experimentally infected mice. Int J Parasitol Drugs Drug Resist. 2024 Aug;25:100553. [Content Brief]

[2]. Wenlin Huang, et al. Development of 5-Aminopyrazole-4-Carboxamide-Based Bumped-Kinase Inhibitors for Cryptosporidiosis Therapy. Journal of Medicinal Chemistry 2019, 62 (6), 3135-3146.

Calculators

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration Concentration

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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Amount: USD 0.00

Biological Activity
- 제품 설명
Chemical Information
순도&문서
References

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BKI 1708

All Parasite Isoforms