Blarcamesine
Based on 3 publication(s) in Google Scholar
Blarcamesine is an orally bioavailable Sigma-1 receptor agonist and muscarinic receptor modulator, with anticonvulsant, anti-amnesic, neuroprotective and antidepressant properties. Blarcamesine ameliorates neurologic impairments in a mouse model of Rett syndrome.
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
- Purity: 99.16%
- CAS No.: 195615-83-9
- 화학식: C19H23NO
- 분자량:281.39
-
보관:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
-
용액&용해도
- 순도&문서
- References
-
Help & FAQs
-
HY-105296R
Blarcamesine (Standard) -
HY-18101A
BD-1063 dihydrochloride -
HY-16996A
BD-1047 dihydrobromide -
HY-18099
S1RA -
HY-14813
Cutamesine -
HY-13510
Cutamesine dihydrochloride -
HY-14221A
Siramesine hydrochloride -
HY-101864
Blarcamesine hydrochloride -
HY-14221
Siramesine -
HY-14218
Ditolylguanidine -
HY-18099A
S1RA hydrochloride -
HY-100155
4-IBP
Publications Citing Use of MedChemExpress (MCE) Blarcamesine
MoreAll Sigma Receptor Isoforms
More
Biological Activity
제품 설명
IC50 & Target
|
Sigma 1 Receptor |
In Vivo
Blarcamesine ameliorates acoustic startle deficit in Mecp2 HET mice[1].
Blarcamesine reverses deficits in visual acuity in older Mecp2 HET mice using the optokinetic response[1].
Blarcamesine produces minimal effects on body weight gain in Mecp2 HET mice[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:Female Mecp2tm1.1Bird/J HET (C57 background) mice[1]
-
Dosage:10 mg/kg, 30 mg/kg
-
Administration:Oral administration, daily, for 6.5 weeks
-
Result:Reverse the deficits observed in the HET animals.
Clinical Trial
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
-
CAS No. 195615-83-9
-
Appearance Solid
-
분자량 281.39
-
화학식 C19H23NO
-
Color White to off-white
-
SMILES
CN(C)CC1C(C2=CC=CC=C2)(C3=CC=CC=C3)OCC1
-
선적
Room temperature in continental US; may vary elsewhere.
-
보관
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (3)
-
Journal Impact Factor
-
Most Recent
-
Arch Toxicol
2024 Oct;98(10):3323-3336. PMID: 38896176 -
Food Chem Toxicol
Lonp1 and Sig-1R contribute to the counteraction of ursolic acid against ochratoxin A-induced mitochondrial apoptosis. [Abstract]2023 Feb:172:113592. PMID: 36587836 -
용액&용해도
In Vitro:
DMSO : 116.67 mg/mL (414.62 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
순도&문서
-
Data Sheet (281 KB)
-
SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Korean - KR (254 KB)
- Portuguese - PT (254 KB)
-
Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.5538 mL | 17.7689 mL | 35.5379 mL | 88.8447 mL |
| 5 mM | 0.7108 mL | 3.5538 mL | 7.1076 mL | 17.7689 mL | |
| 10 mM | 0.3554 mL | 1.7769 mL | 3.5538 mL | 8.8845 mL | |
| 15 mM | 0.2369 mL | 1.1846 mL | 2.3692 mL | 5.9230 mL | |
| 20 mM | 0.1777 mL | 0.8884 mL | 1.7769 mL | 4.4422 mL | |
| 25 mM | 0.1422 mL | 0.7108 mL | 1.4215 mL | 3.5538 mL | |
| 30 mM | 0.1185 mL | 0.5923 mL | 1.1846 mL | 2.9615 mL | |
| 40 mM | 0.0888 mL | 0.4442 mL | 0.8884 mL | 2.2211 mL | |
| 50 mM | 0.0711 mL | 0.3554 mL | 0.7108 mL | 1.7769 mL | |
| 60 mM | 0.0592 mL | 0.2961 mL | 0.5923 mL | 1.4807 mL | |
| 80 mM | 0.0444 mL | 0.2221 mL | 0.4442 mL | 1.1106 mL | |
| 100 mM | 0.0355 mL | 0.1777 mL | 0.3554 mL | 0.8884 mL |
Blarcamesine Related Classifications
HY-105296 Related Classifications
Powered by Bioz