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Cat. No.: HY-120629

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BMS-639623

BMS-639623 is a potent and orally activeCCR3 antagonist with an IC₅₀ of 0.3 nM. BMS-639623 picomolar inhibition potency against eosinophil chemotaxis (IC₅₀=38 pM). BMS-639623 can be used for the research of asthma.

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CAS No.: 675122-44-8
화학식: C₂₅H₃₂FN₇O₂
분자량:481.57

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (264 KB)

BMS-639623 Chemical Structure

CAS No.: 675122-44-8

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- Cellular Effect
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target^[1]

CCR3

0.3 nM (IC₅₀)

All CCR Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
CHO	IC₅₀	0.3 nM Compound: 1, BMS-639623	Displacement of [125I] eotaxin from human CCR3 receptor in CHO cells Displacement of [125I] eotaxin from human CCR3 receptor in CHO cells	[PMID: 18160284]
CHO	IC₅₀	0.3 nM Compound: 31, BMS-639623	Displacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cells Displacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cells	[PMID: 18096386]
CHO	IC₅₀	0.4 nM Compound: 1, BMS-639623	Displacement of [125I] eotaxin from human CCR3/CCR2 chimeric receptor in CHO cells Displacement of [125I] eotaxin from human CCR3/CCR2 chimeric receptor in CHO cells	[PMID: 18160284]
Eosinophil	IC₅₀	0.038 nM Compound: C, BMS-639623	Induction of shape change in human eosinophils by flow cytometry Induction of shape change in human eosinophils by flow cytometry	[PMID: 19010676]

Chemical Information

CAS No. 675122-44-8
분자량 481.57
화학식 C₂₅H₃₂FN₇O₂
SMILES

O=C(NC1=CC=CC(C2=NN=NN2C)=C1)N[C@H](C)[C@@H](O)CN3C[C@H](CC4=CC=C(F)C=C4)CCC3
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (264 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Santella JB 3rd, et al. From rigid cyclic templates to conformationally stabilized acyclic scaffolds. Part I: the discovery of CCR3 antagonist development candidate BMS-639623 with picomolar inhibition potency against eosinophil chemotaxis. Bioorg Med Che [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

견적 받기 해외재고보유

Other size

견적 받기

Amount: USD 0.00

Biological Activity
- 제품 설명
- IC₅₀ & Target
Chemical Information
순도&문서
References

상품명:
Cat. No.:
수량:
MCE Japan Authorized Agent:

상품명:
CAS No.:
Species:
Purity:
수량:

BMS-639623

All CCR Isoforms