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Cat. No.: HY-125191

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BRD1991

BRD1991 selectively disrupts Beclin 1/Bcl-2 binding and induces autophagy without triggering apoptosis or other forms of cell death.

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CAS No.: 2235468-02-5
화학식: C₃₃H₃₅Cl₂N₃O₄
분자량:608.55

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

BRD1991 Chemical Structure

CAS No.: 2235468-02-5

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
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- In Vitro
Chemical Information
순도&문서
References
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Biological Activity

제품 설명

BRD1991 selectively disrupts Beclin 1/Bcl-2 binding and induces autophagy without triggering apoptosis or other forms of cell death^[1].

All Bcl-2 Family Isoforms :

In Vitro

BRD1991 (20 μM, 24 h) can induce complete autophagic flux in HeLa/GFP-LC3 cells, exhibit mild cytotoxicity, and gradually accumulate intracellularly over time^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2235468-02-5
분자량 608.55
화학식 C₃₃H₃₅Cl₂N₃O₄
SMILES

CN1C2=CC=CC=C2C3=C1C(N(C(CO)C)CC(C)C(CN(C(C4=CC(Cl)=CC(Cl)=C4)=O)C)OCC5=CC=CC=C53)=O
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Wei-Chung Chiang, et al. High-Throughput Screens To Identify Autophagy Inducers That Function by Disrupting Beclin 1/Bcl-2 Binding. ACS Chem Biol. 2018 Aug 17;13(8):2247-2260. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
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- In Vitro
Chemical Information
순도&문서
References

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BRD1991

All Bcl-2 Family Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

BRD1991 Related Classifications

HY-125191 Related Classifications