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Cat. No.: HY-138967

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BRF110

BRF110 is the selective, orally active rexinoid for Nurr1-RXRα, that selectively activates the Nurr1-RXRα heterodimer with an EC₅₀ of 0.9 μM in SH-SY5Y. BRF110 upregulates the expression of BDNF, exhibits neuroprotective activity against MPP+ induced toxicity. BRF110 can cross blood-brain barrier.

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CAS No.: 2095489-35-1
화학식: C₂₂H₁₈F₃N₃O₂
분자량:413.39

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

BRF110 Chemical Structure

CAS No.: 2095489-35-1

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

제품 설명

All Nuclear Hormone Receptor 4A/NR4A Isoforms :

All RAR/RXR Isoforms :

Chemical Information

CAS No. 2095489-35-1
분자량 413.39
화학식 C₂₂H₁₈F₃N₃O₂
SMILES

O=C(O)C1=CC=C(N(C)C2=NC(C3=CC=CC=C3)=NC(C(F)(F)F)=C2CC=C)C=C1
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Asvos X, et al., BRF110, an Orally Active Nurr1-RXRα-Selective Rexinoid, Enhances BDNF Expression without Elevating Triglycerides. J Med Chem. 2025 Feb 27;68(4):4763-4786. [Content Brief]

Calculators

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

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Molecular Weight Molecular Weight

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Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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Biological Activity
- 제품 설명
Chemical Information
순도&문서
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BRF110

High-Throughput Bioactive Compound Library

All Nuclear Hormone Receptor 4A/NR4A Isoforms

All RAR/RXR Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

BRF110 Related Classifications

HY-138967 Related Classifications