Butamirate
Based on 1 Customer Validation
Butamirate is an orally active antitussive agent that acts centrally through the receptors in the brainstem. Butamirate also reduces the resistance in the airways by inhibiting bronchospasm and anti-inflammatory effect. Butamirate inhibits glioblastoma (GBM) growth and STAT3 activity. Butamirate can be used for the study of glioblastoma.
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
- Purity: 96.48%
- CAS No.: 18109-80-3
- 화학식: C18H29NO3
- 분자량:307.43
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보관:Pure form -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
- References
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Help & FAQs
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Biological Activity
Butamirate (0.01-10 μM; 7 days) could effectively suppress sphere formation and STAT3 activity[2].
Butamirate effectively inhibits interactions of RRAD with pSTAT3[2].
Butamirate shows decreased EGFR, STAT3, ERK and AKT phosphorylation in U87MG[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:U87MG, U87MG-TMZ-resistant (U87 TMZR), U87MG-Lapatinib-resistant (U87 LAPAR) and T98G (TMZ resistant) tumorspheres
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Concentration:0.01-10 μM
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Incubation Time:7 days
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Result:Effectively suppressed growth of glioblastoma cell lines, including U87MG-TMZR and U87MG-LAPAR.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male BALB/c nude mice (6- to 8 week-old) were subcutaneously injected with U87MG cells[2]
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Dosage:2 mg/kg
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Administration:i.p; once a day; for 36 days.
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Result:Inhibited tumor growth in a glioblastoma mouse xenograft model.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 18109-80-3
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Appearance Liquid (Density: 1.007±0.06 g/cm3)
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분자량 307.43
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화학식 C18H29NO3
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Color Yellow to orange
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SMILES
O=C(C(C1=CC=CC=C1)CC)OCCOCCN(CC)CC
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Pure form -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
용액&용해도
DMSO : 100 mg/mL (325.28 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
순도&문서
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Data Sheet (270 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Płusa T. et al. Butamirate citrate in control of cough in respiratory tract inflammation. Pol Merkur Lekarski. 2017 Aug 21;43(254):69-74. [Content Brief]
[2]. Lee SJ, et al. Application of the antitussive agents oxelaidin and butamirate as anti-glioma agents. Sci Rep. 2021 May 12;11(1):10145. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.2528 mL | 16.2639 mL | 32.5277 mL | 81.3193 mL |
| 5 mM | 0.6506 mL | 3.2528 mL | 6.5055 mL | 16.2639 mL | |
| 10 mM | 0.3253 mL | 1.6264 mL | 3.2528 mL | 8.1319 mL | |
| 15 mM | 0.2169 mL | 1.0843 mL | 2.1685 mL | 5.4213 mL | |
| 20 mM | 0.1626 mL | 0.8132 mL | 1.6264 mL | 4.0660 mL | |
| 25 mM | 0.1301 mL | 0.6506 mL | 1.3011 mL | 3.2528 mL | |
| 30 mM | 0.1084 mL | 0.5421 mL | 1.0843 mL | 2.7106 mL | |
| 40 mM | 0.0813 mL | 0.4066 mL | 0.8132 mL | 2.0330 mL | |
| 50 mM | 0.0651 mL | 0.3253 mL | 0.6506 mL | 1.6264 mL | |
| 60 mM | 0.0542 mL | 0.2711 mL | 0.5421 mL | 1.3553 mL | |
| 80 mM | 0.0407 mL | 0.2033 mL | 0.4066 mL | 1.0165 mL | |
| 100 mM | 0.0325 mL | 0.1626 mL | 0.3253 mL | 0.8132 mL |
Butamirate Related Classifications
HY-118545 Related Classifications
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