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Cat. No.: HY-N19702

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Calphostin B

Calphostin B is a protein kinase C (PKC) inhibitor with an IC₅₀ of 1.04 μM in rats and an IC₅₀ of 22.9 μM for bovine cyclic adenosine monophosphate-dependent protein kinase (PKA). Calphostin B bears aromatic structures at positions C-14 and C-17, which accounts for its higher selectivity for PKC over PKA. Calphostin B can be used in studies related to human cervical cancer and human breast cancer.

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CAS No.: 124824-06-2
화학식: C₃₇H₃₄O₁₁
분자량:654.66

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Calphostin B Chemical Structure

CAS No.: 124824-06-2

Amount: USD 0.00

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target^[1]

PKC

1.04 μM (IC₅₀)

PKA

22.9 μM (IC₅₀)

All PKC Isoforms :

All PKA Isoforms :

In Vitro

Calphostin B inhibits partially purified rat brain PKC with an IC₅₀ of 1.04 μM and partially purified bovine heart PKA with an IC₅₀ of 22.9 μM^[1].
Calphostin B (1 h) inhibits the growth of human cervical cancer HeLa S₃ cells with an IC₅₀ of 2.56 μM and human breast cancer MCF-7 cells with an IC₅₀ of 1.61 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 124824-06-2
분자량 654.66
화학식 C₃₇H₃₄O₁₁
SMILES

O=C(C1=CC=CC=C1)OC(CC2=C(C(C3=C(C=C(C(C4=C5C6=C(O)C=C4OC)=C3C2=C5C(CC(C)O)=C(OC)C6=O)OC)O)=O)OC)C
Structure Classification
- Phenols
- Polyphenols
Initial Source
- Microorganisms
Cladosporium cladosporioides
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Kobayashi E, et al. Calphostins (UCN-1028), novel and specific inhibitors of protein kinase C. I. Fermentation, isolation, physico-chemical properties and biological activities. J Antibiot (Tokyo). 1989 Oct;42(10):1470-4. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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Amount: USD 0.00

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References

상품명:
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Calphostin B

All PKC Isoforms

All PKA Isoforms