Chymostatin
Based on 1 Customer Validation
Chymostatin is a SARS-CoV-2 Mpro inhibitor. Chymostatin up-regulates endocan and inhibits NF-κBp65 activity. Chymostatin reduces proinflammatory cytokines (IL-1β and IL-6) and HMGB1. Chymostatin shows protective effects against Paraquat-induced acute lung injury. Chymostatin exhibits anticancer activity against lung cancer.
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- Purity: 99.9%
- CAS No.: 9076-44-2
- 분자량:607.70
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보관:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
- References
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Help & FAQs
Biological Activity
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NF-κB |
IL-6 |
IL-1β |
Chymostatin (20-150 μM) inhibits cellular aggregation of activated human peripheral blood lymphocytes[2].
Chymostatin (50 μM, 1 h) combined with Aliskiren (HY-12176) to alleviate endoplasmic reticulum stress induced by lipid overload in kidney tubular cells HK2[3].
Chymostatin shows dose-dependent inhibition of COVID-19 Mpro activity with IC50 of 15.81 µM[4].
Chymostatin (up to 100 µM) does not show any cytotoxicity on normal mouse lung epithelial cells, where as it inhibits proliferation of human H441 lung cancer cells (KrasG12V mutant) with IC50 of 1.2 µM[4].
Chymostatin (20 µM) decreases protein breakdown in leg muscles from normal rodents and also in denervated and dystrophic muscles[5].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chymostatin (2 mg/kg/h, i.v.) decreases heart rate, renal blood flow and increases IVR in 2K1C rats[6].
Chymostatin (2 mg/kg/h, i.v.) increases plasma potassium concentrations (17%) in UNX HS rats[6].
. Chymostatin (1 mg/kg, i.p.) retards the decrease in locomotor activity and increases muscle protein in dystrophic mice[7].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Acute lung injury female mice (injected with Paraquat at a dosage of 25 mg/kg)[1]
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Dosage:2 mg/kg
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Administration:Intraperitoneal injection (i.p.), 30 min before paraquat administration
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Result:Did not affect the lung tissue structure.
Decreased the lung W/D ratios, the production of TNF-a, IL-1β, IL-6 and HMGB1.
Decreased the increase in cathepsin G activity.
Increased endocan concentration.
Down-regulated nuclear NF-κBp65 in the lung.
Chemical Information
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CAS No. 9076-44-2
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Appearance Solid
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분자량 607.70
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Color White to off-white
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
용액&용해도
DMSO : 50 mg/mL (82.28 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
순도&문서
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Data Sheet (277 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
[1]. Chen Yang, et al. Protective Effects of Chymostatin on Paraquat-Induced Acute Lung Injury in Mice. Inflammation [Content Brief]
[2]. Lane JT, et al. Chymostatin inhibits cellular aggregation of activated human peripheral blood lymphocytes. Life Sci. 1980 Aug 11;27(6):451-6. [Content Brief]
[3]. Qiu M, et al. Combination of Chymostatin and Aliskiren attenuates ER stress induced by lipid overload in kidney tubular cells. Lipids Health Dis. 2018 Jul 31;17(1):183. [Content Brief]
[5]. Libby P, et al. Effects of chymostatin and other proteinase inhibitors on protein breakdown and proteolytic activities in muscle. Biochem J. 1980 Apr 15;188(1):213-20. [Content Brief]
[6]. Roszkowska-Chojecka MM, et al. Effects of chymostatin, a chymase inhibitor, on blood pressure, plasma and tissue angiotensin II, renal haemodynamics and renal excretion in two models of hypertension in the rat. Exp Physiol. 2015 Sep;100(9):1093-105. [Content Brief]
[7]. Komatsu K, et al. Beneficial effect of chymostatin on dystrophic mice. Exp Neurol. 1986 Jul;93(1):110-6. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.6455 mL | 8.2277 mL | 16.4555 mL | 41.1387 mL |
| 5 mM | 0.3291 mL | 1.6455 mL | 3.2911 mL | 8.2277 mL | |
| 10 mM | 0.1646 mL | 0.8228 mL | 1.6455 mL | 4.1139 mL | |
| 15 mM | 0.1097 mL | 0.5485 mL | 1.0970 mL | 2.7426 mL | |
| 20 mM | 0.0823 mL | 0.4114 mL | 0.8228 mL | 2.0569 mL | |
| 25 mM | 0.0658 mL | 0.3291 mL | 0.6582 mL | 1.6455 mL | |
| 30 mM | 0.0549 mL | 0.2743 mL | 0.5485 mL | 1.3713 mL | |
| 40 mM | 0.0411 mL | 0.2057 mL | 0.4114 mL | 1.0285 mL | |
| 50 mM | 0.0329 mL | 0.1646 mL | 0.3291 mL | 0.8228 mL | |
| 60 mM | 0.0274 mL | 0.1371 mL | 0.2743 mL | 0.6856 mL | |
| 80 mM | 0.0206 mL | 0.1028 mL | 0.2057 mL | 0.5142 mL |
Chymostatin Related Classifications
HY-P3042 Related Classifications
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