CP19
CP19, a histamine receptor antagonist, is an entry inhibitor against both Ebolavirus (EBOV) and Marburgvirus (MARV) with IC50s of 3.4 μM and 29.5 μM, respectively. CP19 has SI values of 29.4 and 3.4 for EBOV and MARV, respectively. CP19 has antiviral activity.
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- CAS No.: 1018148-68-9
- 화학식: C26H30N2O5
- 분자량:450.53
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Protocol
- 순도&문서
- References
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Help & FAQs
All Histamine Receptor Isoforms
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Biological Activity
제품 설명
IC50 & Target
[1]|
EBOV |
MARV |
Histamine Receptor |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | CC50 |
>100 μM
Compound: 1; CP19
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Cytotoxicity against human A549 cells assessed as reduction in cell viability by Celltiter-Glo assay
Cytotoxicity against human A549 cells assessed as reduction in cell viability by Celltiter-Glo assay
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[PMID: 32707357] |
Chemical Information
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CAS No. 1018148-68-9
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분자량 450.53
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화학식 C26H30N2O5
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SMILES
O=C1OC2=C(C(C)=C1CC3=CC=CC=C3)C=CC(OCC(CN4CCC(CC4)C(N)=O)O)=C2
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocol
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Research Protocol for Infectious Diseases
Infectious-disease experiments test how pathogens interact with host barriers, innate immune receptors, inflammatory signaling, pathogen replication, and tissue injury; pattern-recognition receptors such as TLRs, RIG-I-like receptors, NOD-like receptors, and inflammasomes detect microbial molecules and activate NF-κB, interferon, and cytokine responses. The central hypothesis is that infection severity reflects the balance between pathogen burden and host response: protective inflammation restricts pathogen growth, whereas excessive or mislocalized inflammation contributes to tissue damage and disease phenotype. Unresolved questions include which host pathways are protective versus pathogenic, why some infection models fail to translate to human disease, and which combined readouts best predict clinically relevant infection outcomes.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
CP19 Related Classifications
HY-146815 Related Classifications
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