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Cat. No.: HY-189048

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CPN4F

CPN4F is a chalcone derivative with antiparasitic activity. CPN4F is an inhibitor of the cysteine protease cruzain. CPN4F forms a key hydrogen bond with the Trp-184 residue in the active site of parasitic cruzain as an electrophile, and induces oxidative stress, cell membrane degradation, and necrosis, thereby inhibiting parasite proliferation. CPN4F is used in research related to Chagas disease.

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화학식: C₁₈H₁₇FO₅
분자량:332.32

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

CPN4F Chemical Structure

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target

^[1]

Trypanosoma

cathepsin L

All Parasite Isoforms :

All Cathepsin Isoforms :

In Vitro

Parasitic InfectionOthers

Parasitic Infection

CPN4F (15.6-1000 μM; 24-72 h) exerts potent antiproliferative effects on epimastigotes of T. cruzi strain Y, with IC₅₀ values of 356.70 μM, 149.30 μM, and 22.95 μM at 24 h, 48 h, and 72 h, respectively^[1].
CPN4F (31.2-1000 μM; 24 h) exhibits excellent trypanocidal activity against trypomastigotes of T. cruzi strain Y, with an LC₅₀ of 32.54 μM^[1].

Others

CPN4F (15.6-1000 μM; 24 h) exhibits significant cytotoxicity in LLC-MK2 host cells, causing a concentration-dependent decrease in cell viability, with a CC₅₀ of 99.26 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay^[1]

Cell Line:

LLC-MK2 cells
Concentration:

15.6, 31.2, 62.5, 125, 250, 500, 1000 μM
Incubation Time:

24 h
Result:

Exhibited significant host cell toxicity.

Cell Viability Assay^[1]

Cell Line:

Epimastigote forms of T. cruzi strain Y
Concentration:

15.6, 31.2, 62.5, 125, 250, 500, 1000 μM
Incubation Time:

24 h, 48 h, 72 h
Result:

Demonstrated time- and concentration-dependent antiproliferative effects on epimastigotes.

Cell Viability Assay^[1]

Cell Line:

Trypomastigote forms of T. cruzi strain Y
Concentration:

31.2, 62.5, 125, 250, 500, 1000 μM
Incubation Time:

24 h
Result:

Effectively killed the trypomastigotes with LC₅₀ of 32.54 μM.

Related Protocols :

Chemical Information

분자량 332.32
화학식 C₁₈H₁₇FO₅
SMILES

O=C(C1=C(OC)C=C(OC)C(OC)=C1O)/C=C/C2=CC=C(F)C=C2
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Pinto Filho JIL, et al. Evaluation of Chalcone ()‑3-(4-Fluorophenyl)-1-(2-hydroxy-3,4,6-trimethoxyphenyl)-prop-2-en-1-one against (Y Strain): In Vitro Assay, In Silico Drug-Target Analysis, and MPO-Based Drug Likeness. ACS omega. 2026 Aug 04;11(30):44583-44613.

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

견적 받기 해외재고보유

Other size

견적 받기

Amount: USD 0.00

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References

상품명:
Cat. No.:
수량:
MCE Japan Authorized Agent:

상품명:
CAS No.:
Species:
Purity:
수량:

CPN4F

All Parasite Isoforms

All Cathepsin Isoforms

Biological Activity

제품 설명

IC50 & Target

In Vitro

Chemical Information

순도&문서

References

Calculators

Help & FAQs

CPN4F Related Classifications

HY-189048 Related Classifications

Bioz

Keywords

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