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Cat. No.: HY-128562

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CS-1-69

CS-1-69 is an MBD2 ligand analog that does not bind to individual NuRD components MBD2 or HDAC1, but binds robustly to the assembled NuRD complex (MBD2, HDAC1, and MT1A) in a dose-responsive manner. CS-1-69 attenuates Transcriptional Repression via Active Chemical Epigenetic Reprogrammin (TRACER)-mediated strogen receptor (ER) inhibitory activity.

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CAS No.: 315702-79-5
화학식: C₁₄H₁₁N₃OS
분자량:269.32

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Please store the product under the recommended conditions in the Certificate of Analysis.

CS-1-69 Chemical Structure

CAS No.: 315702-79-5

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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Biological Activity

제품 설명

All Estrogen Receptor/ERR Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
HeLa	EC₅₀	<1.2 μM Compound: 21	Inhibition of VCP in human HeLa cells assessed as stabilization of ubiquitin-tagged luciferase after 24 hrs by reporter gene assay Inhibition of VCP in human HeLa cells assessed as stabilization of ubiquitin-tagged luciferase after 24 hrs by reporter gene assay	[PMID: 20137940]
RCC4	GI₅₀	36 μM Compound: 79	Growth inhibition of VHL-null human RCC4 cells after 4 days by XTT assay Growth inhibition of VHL-null human RCC4 cells after 4 days by XTT assay	[PMID: 19994864]

In Vitro

CS-1-69 (0-150 μM; 1 h) binds specifically to the assembled NuRD complex of purified MBD2, HDAC1, and MT1A proteins in a dose-responsive manner, with no binding to isolated MBD2 or HDAC1^[1].
CS-1-69 (25 μM; 24 h) blocks CS-1-103-mediated inhibition of ER transcriptional activity in T47D breast cancer cells, confirming CS-1-103 acts via recruitment of MBD2^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 315702-79-5
분자량 269.32
화학식 C₁₄H₁₁N₃OS
SMILES

OC1=CC=C(NC2=NC(C3=NC=CC=C3)=CS2)C=C1
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Stieger CE, et al. Targeted Transcriptional Repression by Induced Proximity. bioRxiv [Preprint]. 2025 Oct 22:2025.10.22.680877.
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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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CS-1-69

All Estrogen Receptor/ERR Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

CS-1-69 Related Classifications

HY-128562 Related Classifications