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Cat. No.: HY-160948

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DB07006

DB07006 (compound 18) is a potent, ATP-cpmpetitive dual inhibitor of Wee1 (IC₅₀ = 0.030 μM) and Chk1 checkpoint kinases (IC₅₀ = 0.018 μM). DB07006 demonstrates effective abrogation of the G2/M checkpoint in combination with DNA-damaging agents in cellular models. DB07006 can be used for cancer research.

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CAS No.: 622855-60-1
화학식: C₂₄H₂₀N₂O₅
분자량:416.43

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (275 KB)

DB07006 Chemical Structure

CAS No.: 622855-60-1

사이즈

가격

재고

수량

Amount: USD 0.00

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target^[1]

Chk1

0.018 μM (IC₅₀)

Wee1

0.030 μM (IC₅₀)

All Wee1 Isoforms :

PKMYT1

All Checkpoint Kinase (Chk) Isoforms :

Chemical Information

CAS No. 622855-60-1
분자량 416.43
화학식 C₂₄H₂₀N₂O₅
SMILES

O=C1NC(C2=C(C3=C(N4CCCO)C=CC(O)=C3)C4=CC(C5=C(OC)C=CC=C5)=C21)=O
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (275 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Smaill JB, et al. Synthesis and structure-activity relationships of N-6 substituted analogues of 9-hydroxy-4-phenylpyrrolo[3,4-c]carbazole-1,3(2H,6H)-diones as inhibitors of Wee1 and Chk1 checkpoint kinases. Eur J Med Chem. 2008 Jun;43(6):1276-96. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

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Amount: USD 0.00

Biological Activity
- 제품 설명
- IC₅₀ & Target
Chemical Information
순도&문서
References

상품명:
Cat. No.:
수량:
MCE Japan Authorized Agent:

상품명:
CAS No.:
Species:
Purity:
수량:

DB07006

All Wee1 Isoforms

All Checkpoint Kinase (Chk) Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

DB07006 Related Classifications

HY-160948 Related Classifications