E 6080
E 6080 is an orally active and selective 5-lipoxygenase (5-LOX) inhibitor with an IC50 of 0.2 μM in rat basophilic leukemia cell. E 6080 shows potent inhibitory effects on the release of leukotrienes. E 6080 inhibits the bronchospasm induced by antigen (ovalbumin) inhalation in sensitized conscious guinea pigs. E 6080 can be used for the study of asthma.
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- CAS No.: 120164-49-0
- 화학식: C17H20ClN3O3S2
- 분자량:413.94
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
All Leukotriene Receptor Isoforms
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Biological Activity
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5-LOX 0.2 μM (IC50) |
LTB4 |
LTC4 |
E 6080 inhibits both antigen- and anti-human IgE-induced leukotriene C4 generations from lung fragments at similar concentrations: the IC50s of 1.11 μM and 0.96 μM, respectively[2].
E 6080 inhibitS antigen-stimulated LTB4 and LTQ release from passively sensitized human (IC50: LTB4 0.08 µM, LTC4 0.2 µM) and guinea-pig lung fragments (IC50: LTC4 1.1 µM)[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 120164-49-0
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분자량 413.94
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화학식 C17H20ClN3O3S2
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SMILES
O=S(N)(C1=CC=C(CNC2=NC3=C(C)C(C)=C(O)C(C)=C3S2)C=C1)=O.Cl
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
[1]. Tsunoda H, et al. Effect of a novel 5-lipoxygenase inhibitor, E6080 on bronchospasm, airway cellular infiltration and leukotriene production in guinea pigs. Prostaglandins Leukot Essent Fatty Acids. 1991 Jan;42(1):51-6. [Content Brief]
[2]. Katayama S, et al. Inhibition of IgE-mediated leukotriene generation and bronchoconstriction in primates with a new 5-lipoxygenase inhibitor, E6080. Int Arch Allergy Immunol. 1993;100(2):178-84. [Content Brief]
[3]. Sakuma Y, et al. Effects of the new 5-lipoxygenase inhibitor E6080 on leukotriene release in vitro. Int Arch Allergy Immunol. 1992;97(4):267-73. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
E 6080 Related Classifications
HY-180363 Related Classifications
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