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Cat. No.: HY-174372

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EZH2-IN-23

EZH2-IN-23 (Compound 25) is an EZH2 inhibitor that exhibits potent enzymatic inhibition of the PRC2 complex (EZH2, EED, SUZ12, AEBP2, RbAp48) with a biochemical IC₅₀ of 0.8 nM. EZH2-IN-23 inhibits H3K27 trimethylation in cellular assays, showing an IC₅₀ of 40 nM. EZH2-IN-23 displays good rat PKproperties with 100 % oral bioavailability.

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CAS No.: 3095068-20-2
화학식: C₂₉H₃₅ClN₄O₂S
분자량:539.13

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

EZH2-IN-23 Chemical Structure

CAS No.: 3095068-20-2

사이즈

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수량

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- Parmacokinetics
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

All Histone Methyltransferase Isoforms :

Parmacokinetics

Species	Dose	Route	T_1/2	V_ss	CL	AUC_0-inf	F
Rat^[1]	1 mg/kg	i.v.	1.3 h	2.8 L/kg	65 mL/mg/kg	/	/
Rat^[1]	5 mg/kg	p.o.	/	/	/	2226 ng·h/mL	≥100 %

Chemical Information

CAS No. 3095068-20-2
분자량 539.13
화학식 C₂₉H₃₅ClN₄O₂S
SMILES

CC(N1)=CC(C)=C(CN2CCC(SC([C@H](C)C3CCN(CC4=NC=C(Cl)C=C4)CC3)=C5C)=C5C2=O)C1=O
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Tian X, et, al. Asymmetric synthesis of potent and orally bioavailable thiophene-based EZH2 inhibitors. Bioorg Med Chem Lett. 2025 May 30;127:130291.

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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Biological Activity
- 제품 설명
Chemical Information
순도&문서
References

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EZH2-IN-23

All Histone Methyltransferase Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

EZH2-IN-23 Related Classifications

HY-174372 Related Classifications