FGA146
FGA146 is a dual, selective inhibitor for Mpro and human Cathepsin L, with Kis of 2.19 μM, 0.96 μM and 0.87 μM, for Mal-Mpro, pET21-Mpro and Cathepsin L, respectively. FGA146 reveals an antiviral activity against SARS-CoV-2.
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- 화학식: C24H31N5O6
- 분자량:485.53
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
All Cathepsin Isoforms
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Biological Activity
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cathepsin L 0.87 μM (Ki) |
pET21-Mpro 0.96 μM (Ki) |
Mal-Mpro 2.19 μM (Ki) |
FGA146 reveals antiviral activity against SARS-CoV-2 with EC50 of 0.9 μM with low cytotoxicity[1].
FGA146 (25-100 μM) binds covalently to Mpro and decreases its thermal stability[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Huh-7-ACE2
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Concentration:0-100 μM
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Incubation Time:24 h
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Result:Exhibited a CC50 of over 100 μM.
Chemical Information
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분자량 485.53
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화학식 C24H31N5O6
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SMILES
O=C(N[C@@H](C[C@@H]1CCNC1=O)/C=C/[N+]([O-])=O)[C@H](CC(C)C)NC(C2=CC(C(OC)=CC=C3)=C3N2)=O
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
FGA146 Related Classifications
HY-161245 Related Classifications
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