FGA146
FGA146 is a dual, selective inhibitor for Mpro and human Cathepsin L, with Kis of 2.19 μM, 0.96 μM and 0.87 μM, for Mal-Mpro, pET21-Mpro and Cathepsin L, respectively. FGA146 reveals an antiviral activity against SARS-CoV-2.
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- 화학식: C24H31N5O6
- 분자량:485.53
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Protocol
- 순도&문서
- References
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Help & FAQs
All Cathepsin Isoforms
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Biological Activity
제품 설명
IC50 & Target
[1]|
cathepsin L 0.87 μM (Ki) |
pET21-Mpro 0.96 μM (Ki) |
Mal-Mpro 2.19 μM (Ki) |
In Vitro
FGA146 reveals antiviral activity against SARS-CoV-2 with EC50 of 0.9 μM with low cytotoxicity[1].
FGA146 (25-100 μM) binds covalently to Mpro and decreases its thermal stability[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
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Cell Line:Huh-7-ACE2
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Concentration:0-100 μM
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Incubation Time:24 h
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Result:Exhibited a CC50 of over 100 μM.
Chemical Information
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분자량 485.53
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화학식 C24H31N5O6
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SMILES
O=C(N[C@@H](C[C@@H]1CCNC1=O)/C=C/[N+]([O-])=O)[C@H](CC(C)C)NC(C2=CC(C(OC)=CC=C3)=C3N2)=O
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocol
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Research Protocol for Infectious Diseases
Infectious-disease experiments test how pathogens interact with host barriers, innate immune receptors, inflammatory signaling, pathogen replication, and tissue injury; pattern-recognition receptors such as TLRs, RIG-I-like receptors, NOD-like receptors, and inflammasomes detect microbial molecules and activate NF-κB, interferon, and cytokine responses. The central hypothesis is that infection severity reflects the balance between pathogen burden and host response: protective inflammation restricts pathogen growth, whereas excessive or mislocalized inflammation contributes to tissue damage and disease phenotype. Unresolved questions include which host pathways are protective versus pathogenic, why some infection models fail to translate to human disease, and which combined readouts best predict clinically relevant infection outcomes.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
FGA146 Related Classifications
HY-161245 Related Classifications
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