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Cat. No.: HY-169133

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GDCNF-11

GDCNF-11 is a HIM-PROTAC GPX4 degrader based on the chaperone protein HSP90. GDCNF-11 promotes the ubiquitination and degradation of GPX4 through the HSP 90 chaperone complex, reduces endogenous GPX4 expression to induce ferroptosis in HT-1080 cells, and the DC₅₀ value is 0.08 μM (Pink: Target protein ligand (HY-153748); Blue: HSP90 ligand (HY-10212); Black: Linker (HY-W169526)).
(Pink: GPX4 ligand (HY-153748); Blue: HSP90 ligand (HY-10212); Black: linker (HY-159772)).

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

CAS No.: 2991588-80-6
화학식: C₄₈H₅₃Cl₂N₁₃O₅S
분자량:994.99

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

GDCNF-11 Chemical Structure

CAS No.: 2991588-80-6

사이즈

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- Cellular Effect
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

GDCNF-11 is a HIM-PROTAC GPX4 degrader based on the chaperone protein HSP90. GDCNF-11 promotes the ubiquitination and degradation of GPX4 through the HSP 90 chaperone complex, reduces endogenous GPX4 expression to induce ferroptosis in HT-1080 cells, and the DC₅₀ value is 0.08 μM (Pink: Target protein ligand (HY-153748); Blue: HSP90 ligand (HY-10212); Black: Linker (HY-W169526))^[1]. (Pink: GPX4 ligand (HY-153748); Blue: HSP90 ligand (HY-10212); Black: linker (HY-159772)).

IC₅₀ & Target

GPX4

All PROTACs Isoforms :

All Glutathione Peroxidase Isoforms :

GPX1
GPX4

Cellular Effect

Cell Line	Type	Value	Description	References
HT-1080	IC₅₀	0.74 μM Compound: GDCNF-11	Cytotoxicity against human HT-1080 cells incubated for 48 hrs by CCK-8 assay Cytotoxicity against human HT-1080 cells incubated for 48 hrs by CCK-8 assay	[PMID: 39230973]
HT-1080	IC₅₀	35.5 μM Compound: GDCNF-11	Cytotoxicity against human HT-1080 cells incubated for 48 hrs in presence of Fer-1 by CCK-8 assay Cytotoxicity against human HT-1080 cells incubated for 48 hrs in presence of Fer-1 by CCK-8 assay	[PMID: 39230973]

Chemical Information

CAS No. 2991588-80-6
분자량 994.99
화학식 C₄₈H₅₃Cl₂N₁₃O₅S
SMILES

NC1=NC(NCCC2CCN(CC2)C(CN3N=NC(COC4=C(C=C(C=C4)N(C(CCl)=O)C(C(NCCC5=CC=CC=C5)=O)C6=CC=CS6)Cl)=C3)=O)=C(C7=N1)N=CN7CC8=C(C(OC)=C(C=N8)C)C
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Dong J, et al. Heat Shock Protein 90 Interactome-Mediated Proteolysis Targeting Chimera (HIM-PROTAC) Degrading Glutathione Peroxidase 4 to Trigger Ferroptosis[J]. Journal of Medicinal Chemistry, 2024. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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Amount: USD 0.00

Biological Activity
- 제품 설명
- IC₅₀ & Target
Chemical Information
순도&문서
References

상품명:
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GDCNF-11

All PROTACs Isoforms

All Glutathione Peroxidase Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

GDCNF-11 Related Classifications

HY-169133 Related Classifications