ZRSR2 - zinc finger CCCH-type, RNA binding motif and serine/arginine rich 2 Gene

Also Known as URP; ZC3H22; U2AF1L2; U2AF1RS2; U2AF1-RS2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 8233

About ZRSR2

Cytogenetic location: Xp22.2 Genomic coordinates (GRCh38): X:15,790,484-15,823,260 (from NCBI)

This gene has 6 transcripts (splice variants), 211 orthologues, 2 paralogues and is associated with 77 phenotypes. Ubiquitous expression in lymph node (RPKM 3.8), spleen (RPKM 3.5) and 25 other tissues.

Summary

This gene encodes an essential splicing factor. The encoded protein associates with the U2 auxiliary factor heterodimer, which is required for the recognition of a functional 3' splice site in pre-mRNA splicing, and may play a role in network interactions during spliceosome assembly. [provided by RefSeq, Jul 2008]

ZRSR2 Products (1)

mRNA	Protein	Name
NM_005089.4	NP_005080.1	U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA
enables pre-mRNA 3'-splice site binding	IDA IDA: Inferred from direct assay	21041408	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	9237760	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in mRNA splicing, via spliceosome	IMP IMP: Inferred from mutant phenotype	9237760	GOA
involved in spliceosomal complex assembly	IMP IMP: Inferred from mutant phenotype	21041408	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of U12-type spliceosomal complex	IDA IDA: Inferred from direct assay	15146077	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ZRSR2 Protein Structure

zf-CCCH

RRM_5

0
100
200
300
400
482 a.a.

Protein Preferred Names	Protein Names
U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 2	U2 small nuclear ribonucleoprotein auxiliary factor, small subunit 2

ZRSR2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	ZRSR2	Q15696	TEPSIN	Homo sapiens	Q96N21	Y2H Prey Pooling	32296183
Intra	ZRSR2	Q15696	TEPSIN	Homo sapiens	Q96N21	Y2H Array	32296183
Intra	ZRSR2	Q15696	TEPSIN	Homo sapiens	Q96N21	Validated Y2H	32296183
Intra	ZRSR2	Q15696	REP15	Homo sapiens	Q6BDI9	Y2H Array	32296183
Intra	ZRSR2	Q15696	REP15	Homo sapiens	Q6BDI9	Validated Y2H	32296183
Intra	ZRSR2	Q15696	REP15	Homo sapiens	Q6BDI9	Y2H Prey Pooling	32296183
Intra	ZRSR2	Q15696	ZRSR2P1	Homo sapiens	Q15695	Anti Tag CoIP	33961781
Intra	ZRSR2	Q15696	ZRSR2P1	Homo sapiens	Q15695	Anti Tag CoIP	28514442
Intra	ZRSR2	Q15696	ZRSR2P1	Homo sapiens	Q15695	Y2H Array	32296183
Intra	ZRSR2	Q15696	ZRSR2P1	Homo sapiens	Q15695	Y2H Prey Pooling	32296183
Intra	ZRSR2	Q15696	SSX2IP	Homo sapiens	Q9Y2D8	Validated Y2H	25416956
Intra	ZRSR2	Q15696	SSX2IP	Homo sapiens	Q9Y2D8	Y2H Array	25416956
Intra	ZRSR2	Q15696	SSX2IP	Homo sapiens	Q9Y2D8	Anti Tag CoIP	33961781
Intra	ZRSR2	Q15696	CCNL1	Homo sapiens	Q9UK58	Validated Y2H	32296183
Intra	ZRSR2	Q15696	CCNL1	Homo sapiens	Q9UK58	Y2H Array	32296183
Intra	ZRSR2	Q15696	CCNL1	Homo sapiens	Q9UK58	Y2H Prey Pooling	32296183
Intra	ZRSR2	Q15696	LUC7L2	Homo sapiens	Q9Y383	Y2H Array	32296183
Intra	ZRSR2	Q15696	LUC7L2	Homo sapiens	Q9Y383	Validated Y2H	32296183
Intra	ZRSR2	Q15696	LUC7L2	Homo sapiens	Q9Y383	Y2H Prey Pooling	32296183
Intra	ZRSR2	Q15696	SRRM4	Homo sapiens	A7MD48	Y2H Prey Pooling	32296183
Intra	ZRSR2	Q15696	SRRM4	Homo sapiens	A7MD48	Y2H Array	32296183
Intra	ZRSR2	Q15696	SRPK1	Homo sapiens	Q96SB4	Anti Tag CoIP	33961781
Intra	ZRSR2	Q15696	SRPK1	Homo sapiens	Q96SB4	Anti Tag CoIP	28514442
Intra	ZRSR2	Q15696	SRPK2	Homo sapiens	P78362	Y2H Prey Pooling	25416956
Intra	ZRSR2	Q15696	SRPK2	Homo sapiens	P78362	Anti Tag CoIP	33961781
Intra	ZRSR2	Q15696	SRPK2	Homo sapiens	P78362	Y2H Prey Pooling	32296183
Intra	ZRSR2	Q15696	SRPK2	Homo sapiens	P78362	Protein Kinase Assay	23602568
Intra	ZRSR2	Q15696	SRPK2	Homo sapiens	P78362	Y2H Array	32296183
Intra	ZRSR2	Q15696	SDCBP2	Homo sapiens	Q9H190	Y2H Array	32296183
Intra	ZRSR2	Q15696	SDCBP2	Homo sapiens	Q9H190	Y2H Array	31515488
Intra	ZRSR2	Q15696	CLK2	Homo sapiens	P49760	Validated Y2H	25416956
Intra	ZRSR2	Q15696	SDCBP2	Homo sapiens	Q9H190	Y2H Prey Pooling	25416956
Intra	ZRSR2	Q15696	CLK2	Homo sapiens	P49760	Y2H Prey Pooling	25416956
Intra	ZRSR2	Q15696	SDCBP2	Homo sapiens	Q9H190	Y2H Prey Pooling	32296183
Intra	ZRSR2	Q15696	SDCBP2	Homo sapiens	Q9H190	Validated Y2H	32296183
Intra	ZRSR2	Q15696	SDCBP2	Homo sapiens	Q9H190	Y2H Array	25416956
Intra	ZRSR2	Q15696	SRSF5	Homo sapiens	Q13243	Y2H Prey Pooling	32296183
Intra	ZRSR2	Q15696	SRSF5	Homo sapiens	Q13243	Y2H Array	32296183
Intra	ZRSR2	Q15696	DVL3	Homo sapiens	Q92997	Y2H Array	32296183
Intra	ZRSR2	Q15696	DVL3	Homo sapiens	Q92997	Validated Y2H	32296183
Intra	ZRSR2	Q15696	DVL3	Homo sapiens	Q92997	Y2H Prey Pooling	32296183
Intra	ZRSR2	Q15696	CLK2	Homo sapiens	P49760	Y2H Prey Pooling	32296183
Intra	ZRSR2	Q15696	CLK2	Homo sapiens	P49760	Y2H Array	32296183
Intra	ZRSR2	Q15696	TNFAIP8L1	Homo sapiens	Q8WVP5	Validated Y2H	32296183
Intra	ZRSR2	Q15696	TNFAIP8L1	Homo sapiens	Q8WVP5	Y2H Prey Pooling	32296183
Intra	ZRSR2	Q15696	TNFAIP8L1	Homo sapiens	Q8WVP5	Y2H Array	32296183
Intra	ZRSR2	Q15696	KHDC4	Homo sapiens	Q7Z7F0-4	Y2H Prey Pooling	32296183
Intra	ZRSR2	Q15696	KHDC4	Homo sapiens	Q7Z7F0-4	Validated Y2H	32296183
Intra	ZRSR2	Q15696	KHDC4	Homo sapiens	Q7Z7F0-4	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Holoprosencephaly 1	Arhinencephaly HPE1 Cyclopia Holoprosencephaly, Familial Alobar Hpe, Familial Hpec Demyer Sequence Holoprosencephaly-1
Holoprosencephaly	Holoprosencephaly Sequence Hpe Hpe - [Holoprosencephaly]
Heart Disease	Heart Failure Congenital Heart Disease Heart Diseases Congenital Heart Defects Congenital Heart Defect Heart Malformation Congenital Anomaly Of Heart Heart Defect Heart-Congenital Defect Congenital Heart Disorder Heart Defects Congenital Heart Defects, Congenital Heart Defects Heart Disease, Congenital Disease, Heart, Congenital Congestive Heart Failure
Vexas Syndrome	VEXAS Vexas Syndrome, Somatic Vacuoles, E1 Enzyme, X-Linked, Autoinflammatory And Somatic Syndrome Vacuoles, E1 Enzyme, X-Linked, Autoinflammatory, Somatic Syndrome Vacuoles, E1 Enzyme, X-Linked, Autoinflammatory, Somatic
Chronic Leukemia	Adult Chronic Leukemia Cll Cml
Atypical Chronic Myeloid Leukemia, Bcr-Abl1 Negative	Atypical Chronic Myeloid Leukemia Atypical Chronic Myeloid Leukaemia Leukemia, Myeloid, Chronic, Atypical, Bcr-Abl Negative Acml Atypical Chronic Myeloid Leukaemia Bcr-Abl1 Negative Atypical Chronic Myeloid Leukemia Bcr-Abl1 Negative Atypical Cml Subacute Myeloid Leukemia Subacute Myelogenous Leukaemia Subacute Myeloid Leukaemia Subacute Myelosis Atypical Chronic Myeloid Leukaemia, Bcr-Abl-Negative Without Mention Of Remission Subacute Monocytic Leukaemia Without Mention Of Remission Subacute Monocytic Leukaemia
Microcephalic Osteodysplastic Primordial Dwarfism, Type I	Taybi-Linder Syndrome Brachymelic Primordial Dwarfism Cephaloskeletal Dysplasia Low-Birth-Weight Dwarfism With Skeletal Dysplasia Microcephalic Osteodysplastic Primordial Dwarfism Type I Osteodysplastic Primordial Dwarfism Type I Primordial Microcephalic Dwarfism, Crachami Type Osteodysplastic Primordial Dwarfism, Type 1 MOPD1 Mopd I Mopd Osteodysplastic Primordial Dwarfism, Type I Tals Microcephalic Osteodysplastic Primordial Dwarfism Type 1 Mopd 1 Microcephalic Osteodysplastic Primordial Dwarfism Types 1 And 3 Microcephalic Osteodysplastic Primordial Dwarfism Types I And Iii Mopd Types I And Iii Microcephalic Osteodysplastic Primordial Dwarfism, Taybi-Linder Type Primordial Microcephalic Dwarfism Crachami Type Dwarfism, Primordial, Osteodysplastic, Microcephalic, Type 1
Myelodysplastic/Myeloproliferative Neoplasm	Myelodysplastic-Myeloproliferative Diseases Myelodysplastic/Myeloproliferative Disease Myelodysplastic Myeloproliferative Cancer Myelodysplastic Myeloproliferative Disease Myeloproliferative/Myelodysplastic Syndromes
Chronic Myelomonocytic Leukemia	Leukemia, Myelomonocytic, Chronic Cmml Leukemia Myelomonocytic Chronic Cmml - [Chronic Myelomonocytic Leukaemia] Chronic Myelomonocytic Leukaemia Without Mention Of Remission Chronic Monocytic Leukaemia Chronic Monocytoid Leukaemia
Lung Cancer	Lung Carcinoma Non-Small Cell Lung Carcinoma Lung Cancer, Susceptibility To Lung Cancer, Protection Against Adenocarcinoma Of Lung, Somatic Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer Lung Neoplasm Carcinoma Of Lung Lung Non-Small Cell Carcinoma Non-Small Cell Lung Cancer Nsclc Lung Neoplasms Malignant Neoplasm Of Lung Alveolar Cell Carcinoma Nonsmall Cell Lung Cancer, Somatic Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer, Susceptibility To Lung Cancer, Somatic Lung Cancer, Resistance To Cancer Of Lung Cancer Of Bronchus Cancer Of The Lung Lung Malignancies Lung Malignant Tumors Malignant Lung Tumor Malignant Tumor Of Lung Pulmonary Cancer Pulmonary Carcinoma Pulmonary Neoplasms Respiratory Carcinoma LNCR Adenocarcinoma Of Lung Neoplasm Of Lung Cancer Lung Carcinoma Non-Small Cell Lung Carcinoma, Non-Small-Cell Lung Lung Cancers Lung Carcinomas Cancer, Lung Cancer, Lung, Non-Small Cell Primary Malignant Neoplasm Of Lung Bronchioloalveolar Adenocarcinoma
Essential Thrombocythemia	Essential Thrombocytosis Familial Thrombocytosis Hemorrhagic Thrombocythemia Hereditary Thrombocythemia Primary Thrombocytosis Idiopathic Thrombocythemia Primary Thrombocythemia Thrombocythemia, Essential Essential Thrombocythaemia Et Familial Thrombocythemia Thrombocythemia Essential
Juvenile Myelomonocytic Leukemia	Leukemia, Juvenile Myelomonocytic JMML Leukemia, Juvenile Myelomonocytic, Somatic Juvenile Chronic Myelomonocytic Leukemia Juvenile Chronic Myelogenous Leukemia Leukemia, Myelomonocytic, Juvenile Juvenile Myelomonocytic Leukaemia Without Mention Of Remission
Myelodysplastic Syndrome	Myelodysplastic Syndromes Myelodysplasia MDS Myelodysplastic Syndrome Included Myelodysplastic Syndrome, Susceptibility To, Included Myelodysplastic Syndrome, Somatic Myelodysplastic Syndrome, Susceptibility To
Melanoma, Uveal	Uveal Melanoma Choroidal Melanoma Melanoma Of Uvea Iris Melanoma Malignant Melanoma Of Choroid Malignant Melanoma Of Iris
Leukemia, Acute Myeloid	Acute Myeloid Leukemia Leukemia, Acute Myelogenous Acute Myelogenous Leukemia AML Leukemia, Acute Myeloid, Susceptibility To Acute Myeloblastic Leukemia Leukemia, Acute Myeloid, Reduced Survival In, Somatic Acute Myeloid Leukaemia Leukemia, Myelocytic, Acute Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome Secondary Aml Acute Myelocytic Leukemia Acute Myeloid Leukemia, Somatic Leukemia, Acute Myeloid, Somatic Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic Acute Myeloblastic Leukaemia Acute Myelogenous Leukaemia Aml - Acute Myeloid Leukemia Acute Myeloid Leukemia With Cebpa Somatic Mutations Aml With Cebpa Somatic Mutations Inherited Acute Myeloid Leukemia Familial Aml Inherited Aml Pure Familial Aml Pure Familial Acute Myeloid Leukemia Secondary Acute Myeloid Leukemia Therapy-Related Aml And Myelodysplastic Syndrome Acute Myeloid Leukemia, Secondary Acute Non-Lymphoblastic Leukemia Acute Non-Lymphocytic Leukemia Acute Biphenotypic Leukemia Acute Undifferentiated Leukemia Acute Myeloblastic Leukaemia With Multilineage Dysplasia Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission Acute Myeloid Leukaemia With Myelodysplasia-Related Features
Leukemia, Chronic Lymphocytic	Chronic Lymphocytic Leukemia B-Cell Chronic Lymphocytic Leukemia CLL B-Cell Chronic Lymphoid Leukemia Chronic Lymphatic Leukemia Chronic Lymphocytic Leukaemia Lymphoplasmacytic Leukemia Small Lymphocytic Lymphoma Leukemia, Chronic Lymphatic B-Cell Chronic Lymphocytic Leukaemia Chronic Lymphatic Leukaemia Lymphoplasmacytic Leukaemia B Cell Chronic Lymphocytic Leukemia Chronic B-Cell Lymphocytic Leukemia Leukemia, Lymphocytic, Chronic B-Cll Chronic Lymphoid Leukemia Leukemia Lymphocytic Chronic Lymphoma Small Lymphocytic Leukemia, Lymphocytic, Chronic, B-Cell

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	상품명	효과	Purity	Rare Diseases
HY-RS16196	ZRSR2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	ZRSR2	RGD	RGD:1559763
Mus musculus	ZRSR2	MGD	MGI:103287
Others	ZRSR2	NCBI