Gum arabic
Based on 1 Customer Validation
Gum Arabic is an orally active complex branched polysaccharide. Gum Arabic can be isolated from the Acacia senegal tree. Gum Arabic upregulates the expression of maturation markers (CD86, CD40, and CD54), promotes ERK1/2 phosphorylation, and inhibits Apoptosis. Gum Arabic exhibits antimalarial effects against Plasmodium berghei ANKA. Gum Arabic exhibits hepatoprotective, renal, and cardiovascular protective activities. Gum Arabic improves obesity. Gum Arabic is commonly used as a stabilizer and thickener. Gum Arabic can be used in the research of brain tumor imaging.
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- CAS No.: 9000-01-5
- 분자량:200-300
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보관:
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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용액&용해도
- Protocol
- 순도&문서
- References
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Help & FAQs
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Biological Activity
제품 설명
In Vitro
Gum arabic (0.5%; 24 h) upregulates the expression of maturation markers (CD86, MHCII, CD40, CD54) in mouse bone marrow-derived dendritic cells (DCs)[6].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Mouse bone marrow-derived dendritic cells (DCs)
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Concentration:0.5%
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Incubation Time:10 min, 60 min, 120 min
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Result:Strongly stimulated ERK1/2 phosphorylation.
In Vivo
Gum arabic (2.5%-10.0%; p.o. via drinking water; 8 consecutive days) does not significantly alter the concentrations of free radical scavengers (GSH, AA, SOD) or lipid peroxidation in rats[2].
Gum arabic (3-6 g/100 mL; p.o. via drinking water; 5 weeks) is not effective in reversing body weight decrease or reducing elevated creatinine and urea levels in rats with chronic renal failure (kidney remnant model)[2].
Gum arabic (10%; p.o. via drinking water; starting 10 days before infection) slightly decreases parasitaemia and significantly extends the lifespan of SV129/J wild-type mice infected with Plasmodium berghei ANKA[5].
Gum arabic (15% w/v; p.o. via drinking water; 4 weeks) mitigates Adenine-induced chronic kidney disease (CKD) in male CD1 mice by reducing duodenal inflammation, oxidative and nitrosative stress, and improving renal function (decreasing plasma urea, creatinine and urine albumin)[8].
Gum arabic (15% w/v; p.o. via drinking water) ameliorates water-pipe smoke (WPS)-induced cardiovascular toxicity in C57BL/6 mice, including reducing thrombosis, lowering systolic blood pressure, inhibiting cardiac inflammation and oxidative stress, and preventing myocardial DNA damage and apoptosis [9].
Gum arabic (10% w/w; p.o. via diet; 12 weeks) suppresses high-fat diet-induced obesity in mice by reducing body weight, visceral adipose tissue (VAT) weight, blood glucose and plasma lipids (total cholesterol, LDL, VLDL), and regulating hepatic lipid metabolism-related genes[10].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male Swiss albino mice (25-30 g) with Acetaminophen-induced hepatotoxicity[1]
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Dosage:100 g/L
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Administration:Oral administration via drinking water, 5-day pretreatment before intraperitoneal injection of acetaminophen
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Result:Decreased serum ALT and AST activities.
Reduced hepatic lipid peroxidation.
Did not alter Acetaminophen-induced hepatic glutathione depletion.
- Kinase activity and phosphorylation assays
- RNA extraction experimental
- Western Blot
- Detection of Apoptosis
- TUNEL staining for apoptotic DNA fragmentation
- Annexin V plus membrane-impermeant dye apoptosis staining
- Apoptosis Solutions
- Glioma/Brain Tumor 3D Invasion Assay
- Protocol for Kinase activity and phosphorylation assays
- Bioluminescent/Fluorescent Imaging Xenograft
- Research Protocol for Metabolic Diseases
Clinical Trial
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 9000-01-5
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Appearance Solid
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분자량 200-300
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Color Off-white to light yellow
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SMILES
[Gum arabic]
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Synonyms
Arabic gum
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Structure Classification
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선적
Room temperature in continental US; may vary elsewhere.
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보관
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
용액&용해도
In Vitro:
H2O : ≥ 50 mg/mL
* "≥" means soluble, but saturation unknown.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
순도&문서
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Data Sheet (273 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[2]. Ali BH , et al. Biological effects of gum arabic: a review of some recent research. Food Chem Toxicol. 2009 Jan;47(1):1-8. [Content Brief]
[3]. Gilerovitch HG, et al. The use of electron microscopic immunocytochemistry with silver-enhanced 1.4-nm gold particles to localize GAD in the cerebellar nuclei. J Histochem Cytochem. 1995 Mar;43(3):337-43. [Content Brief]
[5]. Ballal A, et al. Anti-malarial effect of gum arabic. Malar J. 2011 May 20;10:139. [Content Brief]
[6]. Xuan NT, et al. Stimulation of mouse dendritic cells by Gum Arabic. Cell Physiol Biochem. 2010;25(6):641-8. [Content Brief]
[7]. Zhang L, et al. Gum arabic-coated magnetic nanoparticles for potential application in simultaneous magnetic targeting and tumor imaging. AAPS J. 2009 Dec;11(4):693-9. [Content Brief]
[8]. Ali BH, et al. Gum arabic reduces inflammation, oxidative, and nitrosative stress in the gastrointestinal tract of mice with chronic kidney disease. Naunyn Schmiedebergs Arch Pharmacol. 2020 Aug;393(8):1427-1436. [Content Brief]
[9]. Nemmar A, et al. Gum Arabic Ameliorates Impaired Coagulation and Cardiotoxicity Induced by Water-Pipe Smoke Exposure in Mice. Front Physiol. 2019 Feb 25;10:53. [Content Brief]
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