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Cat. No.: HY-182474

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INDOPY-1

Name: INDOPY-1
Brand: MedChemExpress
SKU: HY-182474
Availability: PreOrder

(Synonyms: Indolopyridone-1)

INDOPY-1 (Indolopyridone-1) is a selective, reversible, and competitive HIV-1 reverse transcriptase inhibitor. INDOPY-1 reversibly binds to the active site of reverse transcriptase. INDOPY-1 inhibits DNA synthesis. INDOPY-1 exhibits antiviral activity against various retroviruses, including HIV-1 IIIB, HIV-1 HXB2 K103N Y181C, HIV-2 ROD, and SIV Mac251. INDOPY-1 can be used in the research of immunodeficiency virus infection.

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CAS No.: 352548-47-1
화학식: C₁₉H₁₂N₄O₃
분자량:344.32

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

INDOPY-1 Chemical Structure

CAS No.: 352548-47-1

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target^[1]

HIV-1

HIV-2

All DNA/RNA Synthesis Isoforms :

All HIV Isoforms :

In Vitro

INDOPY-1 inhibits DNA synthesis, with an IC₅₀ of 0.29 μM measured using Poly (rA) · poly (dT) and an IC₅₀ of 1.1 μM measured using Poly (rI) · poly (dC)^[1].
INDOPY-1 exhibits antiviral activity against diverse retroviruses, including HIV-1 IIIB, HIV-1 HXB2 K103N Y181C, HIV-2 ROD, and SIV Mac251^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 352548-47-1
분자량 344.32
화학식 C₁₉H₁₂N₄O₃
SMILES

N#CC(C(N1C2=CC=C([N+]([O-])=O)C=C2)=O)=CC(N3C)=C1C4=C3C=CC=C4
Synonyms

Indolopyridone-1
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Jochmans D, et al. Indolopyridones inhibit human immunodeficiency virus reverse transcriptase with a novel mechanism of action. J Virol. 2006;80(24):12283-12292. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

MOQ

Minimum order quantity

100 mg

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Amount: USD 0.00

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References

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INDOPY-1

All DNA/RNA Synthesis Isoforms

All HIV Isoforms