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United States

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Cat. No.: HY-174994

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JY-5

JY-5 is an E3 ligase ligand that can bind to TRIM28, RACK1, LMO7 and FUS. JY-5 can be used for synthesis of PROTAC JY-21 (HY-174975).

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

화학식: C₂₀H₂₇N₃O₃Si
분자량:385.53

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (276 KB)

JY-5 Chemical Structure

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

제품 설명

JY-5 is an E3 ligase ligand that can bind to TRIM28, RACK1, LMO7 and FUS. JY-5 can be used for synthesis of PROTAC JY-21 (HY-174975)^[1].

All Ligands for E3 Ligase Isoforms :

Chemical Information

분자량 385.53
화학식 C₂₀H₂₇N₃O₃Si
SMILES

CC(C)[Si](C(C)C)(C(C)C)C#C/N=N/C(C([N+]([O-])=O)=C1)=CC=C1OCC#C
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (276 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Du J,et al. Azoacetylene Electrophiles for Proteome-wide Ligand and Target Discovery: Supporting Targeted Protein Degradation. J Med Chem. 2025 Jul 10;68(13):13516-13531. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

견적 받기 해외재고보유

Other size

견적 받기

Amount: USD 0.00

Biological Activity
- 제품 설명
Chemical Information
순도&문서
References

상품명:
Cat. No.:
수량:
MCE Japan Authorized Agent:

상품명:
CAS No.:
Species:
Purity:
수량:

JY-5

All Ligands for E3 Ligase Isoforms

Biological Activity

제품 설명

Chemical Information

순도&문서

References

Calculators

Help & FAQs

JY-5 Related Classifications

HY-174994 Related Classifications

Bioz

Keywords

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