LH17
LH17, a Kaempferol (HY-14590) derivative, is a potent and selective PDE4 inhibitor (PDE4D2 IC50 = 73 nM, PDE4B2 IC50 = 190 nM). LH17 exhibits remarkable selectivity (>136-fold) against other PDE isoforms (PDE1B/2A/3A/5A/8A/9A/10A) (IC50 > 10000 nM), with the exception of PDE7A1 (IC50 = 300 nM). LH17 distinctly interacts with PDE4 M-pocket. LH17 demonstrates remarkable anti-fibrotic efficacy in both in vitro and in vivo models. LH17 can be used for idiopathic pulmonary fibrosis (IPF) research.
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- 화학식: C28H25NO6
- 분자량:471.50
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- 순도&문서
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Help & FAQs
Biological Activity
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PDE4D2 73 nM (IC50) |
PDE4B2 190 nM (IC50) |
PDE7A1 300 nM (IC50) |
PDE1B2 >10000 nM (IC50) |
PDE2A >10000 nM (IC50) |
PDE3A >10000 nM (IC50) |
PDE5A1 >10000 nM (IC50) |
PDE7A1 >10000 nM (IC50) |
PDE8A1 >10000 nM (IC50) |
PDE9A1 >10000 nM (IC50) |
PDE10A1 >10000 nM (IC50) |
Chemical Information
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분자량 471.50
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화학식 C28H25NO6
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SMILES
CC1(C)OC2=CC3=C(C(C(OC)=C(C4=CC=C(OC)C=C4)O3)=O)C(OCC5=CC=NC=C5)=C2C=C1
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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