MGD-4
MGD-4 is an orally active, Cereblon (CRBN)-dependent IKAROS protein degrader that degrades IKZF1 (DC50=67.2 nM), IKZF2 (DC50=918.2 nM), and IKZF3 (DC50=95.8 nM) in a dose-dependent manner. MGD-4 effectively inhibits the growth of multiple myeloma.
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- CAS No.: 2991817-99-1
- 화학식: C14H16N4O3
- 분자량:288.30
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보관:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
Biological Activity
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IKZF1 67.2 nM (DC50) |
IZKF2 918.2 nM (DC50) |
IKZF3 95.8 nM (DC50) |
Chemical Information
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CAS No. 2991817-99-1
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Appearance Solid
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분자량 288.30
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화학식 C14H16N4O3
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Color Off-white to light yellow
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SMILES
O=C1N(C2C(NC(CC2)=O)=O)N(C)CC3=C(N)C=CC=C31
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선적
Room temperature in continental US; may vary elsewhere.
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보관
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
순도&문서
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Data Sheet (269 KB)
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SDS (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
MGD-4 Related Classifications
HY-168614 Related Classifications
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