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Cat. No.: HY-125279

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OAT-2068

OAT-2068 is a selective, high activity and orally active inhibitor of mouse chitotriosidase (mCHIT1) (IC₅₀=29 nM) and displays 143-fold selectivity over m AMCase (IC₅₀=4170 nM). OAT-2068 displays a good pharmacokinetic profile and is an ideal tool to study the role of CHIT1 in biological systems, including animal models of human diseases.

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CAS No.: 2221950-65-6
화학식: C₂₃H₃₆ClN₇
분자량:446.03

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

OAT-2068 Chemical Structure

CAS No.: 2221950-65-6

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target

IC50: 29 nM (mCHIT1); 4200 nM (mAMCase)
IC50: 67 nM (hCHIT1); 1300 nM (hAMCase)^[2]

All Parasite Isoforms :

In Vitro

OAT-2068 is a potent inhibitor developed for mAMCase (IC₅₀=4200 nM) and mCHIT1(IC₅₀=29 nM), which also displays activity toward hAMCase (IC₅₀=67 nM) and hCHIT1 (IC₅₀=1300 nM), it exhibits off-target activity toward the human ether-a-go-go-related gene (hERG)(hERG IC₅₀=2.4 μM)^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

OAT-2068 (intravenous injection; 3 mg/kg; single dose) displays a favorable pharmacokinetic profile, showing moderate plasma clearance (1.71 mg*kg/L),good volume of distribution (4.6 L/h/kg), and T_1/2 (2.87 h) in female BALB/c mice^[1].
OAT-2068 (oral administartion; 10 mg/kg; single dose) displays a favorable pharmacokinetic profile,it is rapidly absorbed with T_max 0.5 h and exhibited a high bioavailability of 61%, the T_1/2 and the plasma clearance are 2.83 hours and 3.57 mg*kg/L, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2221950-65-6
분자량 446.03
화학식 C₂₃H₃₆ClN₇
SMILES

NC1=NNC(N2CCC(N3[C@@H](CC4=CC=C(Cl)C=C4)CN(CC(C)C)[C@@H](C)C3)CC2)=N1
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Marzena Mazur, et al. Discovery of selective, orally bioavailable inhibitor of mouse chitotriosidase. Bioorg Med Chem Lett. 2018 Feb 1;28(3):310-314. [Content Brief]

[2]. Gleb Andryianau, et al. Benzoxazepine-Derived Selective, Orally Bioavailable Inhibitor of Human Acidic Mammalian Chitinase. ACS Med Chem Lett [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

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Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
순도&문서
References

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OAT-2068

All Parasite Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

OAT-2068 Related Classifications

HY-125279 Related Classifications