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Ompenaclid

(Synonyms: RGX-202; 3-Guanidinopropionic acid)
6 Cited Publications
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Based on 6 publication(s) in Google Scholar

Ompenaclid (RGX-202) is an oral small-molecule SLC6A8 transporter inhibitor. Ompenaclid robustly inhibits creatine import in vitro and in vivo, reduces intracellular phosphocreatine and ATP levels, and induces tumor apoptosis. Ompenaclid can be used for the research of cancer and duchenne muscular dystrophy.

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  • Purity: 99.94%
  • CAS No.: 353-09-3
  • 화학식: C4H9N3O2
  • 분자량:131.14
  • 보관:
    Powder   -20°C, 3 years , 4°C, 2 years ; In solvent   -80°C, 6 months , -20°C, 1 month
  • Ompenaclid Chemical Structure
    Ompenaclid Chemical Structure
  • Experimental Validation Results for Ompenaclid
  • Experimental Validation Results for Ompenaclid
  • Experimental Validation Results for Ompenaclid
  • Experimental Validation Results for Ompenaclid
  • Experimental Validation Results for Ompenaclid
CAS No.: 353-09-3
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  • Ompenaclid Chemical Structure
    Ompenaclid Chemical Structure
    1/16
  • 1/16

    Ompenaclid purchased from MedChemExpress. Usage Cited in: Gut Microbes. 2025 Dec;17(1):2489072. [Abstract]

    Customer Validation
     Ompenaclid (RGX-202: 800 mg/kg). Protein bands of AMPKα, p-AMPKα, ACC, p-ACC, ACSL4 and COX2 in mouse ileum.

  • 1/16

    Ompenaclid purchased from MedChemExpress. Usage Cited in: Gut Microbes. 2025 Dec;17(1):2489072. [Abstract]

    Customer Validation
     TUNEL staining shows the effect of RGX-202 (Ompenaclid: 800 mg/kg) administration on DTRF radioprotection. Dead cells are shown as green fluorescence. Cell nuclei are stained with DAPI (blue).

  • 1/16

    Ompenaclid purchased from MedChemExpress. Usage Cited in: Res Sq. 2024 Aug 06.

    Customer Validation
     HE staining revealing the impact of RGX-202 (Ompenaclid：800 mg/kg) administration on the radioprotection of DTRF.

  • 1/16

    Ompenaclid purchased from MedChemExpress. Usage Cited in: Oncoimmunology. 2023 Apr 19;12(1):2204015. [Abstract]

    Customer Validation
     Intracellular and extracellular levels of creatine in WT BMDCs treated with PBS or Ompenaclid (RGX202).

  • 1/16

    Ompenaclid purchased from MedChemExpress. Usage Cited in: Oncoimmunology. 2023 Apr 19;12(1):2204015. [Abstract]

    Customer Validation
     Ompenaclid (RGX202). CD8 levels in T cells and IFN-γ levels in CD8+ T cells co-cultured with BMDCs.

  • Ompenaclid