Reticulol
Reticulol (K 251-1) is an inhibitor of cyclic adenosine 3', 5'-monophosphate phosphodiesterase. Reticulol shows antitumor activity independent with cell cycle arrest or apoptosis. Reticulol inhibits cell growth of murine melanoma cells and human lung tumor cells. Reticulol protects its lung metastasis via the bloodstream by inhibiting the growth of B16F10 melanoma.
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- CAS No.: 26246-41-3
- 화학식: C11H10O5
- 분자량:222.19
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Protocol
- 순도&문서
- References
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Help & FAQs
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Biological Activity
제품 설명
In Vitro
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Pathogen-free female C57BL/6J mice[1]
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Dosage:10 mg/kg, 50 mg/kg
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Administration:IV via the tail vein; day 3 and day 5 after tumor implanted
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Result:Inhibited tumor growth.
- Annexin V plus membrane-impermeant dye apoptosis staining
- BrdU Incorporation Assay
- Somatic Cell Culture
- Protocol for Cell Cycle
- CCK-8/WST-8 Cell Proliferation Assay
- Cell Counting-Based Growth Curve Assay
- Cell Viability Determination by MTT Colorimetric Assay
- Detection of Apoptosis
- TUNEL staining for apoptotic DNA fragmentation
- Flow cytometric DNA-content cell-cycle staining
- Protocol for Cell Counting and Cell Density Analysis
- Tail-Vein Experimental Metastasis Xenograft
- Apoptosis Solutions
- Subcutaneous Cell-Line-Derived Xenograft
- MTT Cell Proliferation Assay
- Orthotopic Cell-Line Xenograft
Chemical Information
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CAS No. 26246-41-3
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분자량 222.19
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화학식 C11H10O5
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SMILES
O=C1C2=C(O)C(OC)=C(O)C=C2C=C(C)O1
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Synonyms
K 251-1
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Structure Classification
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Initial Source
Streptoverticillium album
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
[1]. Furutani Y, et al. Reticulol, an inhibitor of cyclic adenosine 3', 5'-monophosphate phosphodiesterase. J Antibiot (Tokyo). 1975 Jul;28(7):558-60. [Content Brief]
[2]. Lim DS, et al. Antitumor efficacy of reticulol from Streptoverticillium against the lung metastasis model B16F10 melanoma. Lung metastasis inhibition by growth inhibition of melanoma. Chemotherapy. 2003 Jun;49(3):146-53. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Reticulol Related Classifications
HY-120241 Related Classifications
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