SB 706504
SB 706504 is a potent p38 MAPK inhibitor that inhibits Lipopolysaccharides (HY-D1056)-stimulated inflammatory gene expression in macrophages in chronic obstructive pulmonary disease (COPD).
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- CAS No.: 911110-38-8
- 화학식: C24H19F3N8O
- 분자량:492.46
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
Biological Activity
SB 706504(3 μM, 6 h) significantly reduces IL-1β, IL-6, GM-CSF, TNFα and IL-8 mRNA levels in LPS-stimulated monocyte derived macrophages (MDMs) cells[1].
SB 706504(3 μM, 6 h) can significantly reduce the level of TNFα induced by LPS in alveolar macrophages (AMs) cells of COPD patients, with an inhibition rate of 67.4%[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 911110-38-8
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분자량 492.46
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화학식 C24H19F3N8O
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SMILES
N=C(NCCNC1=NC(C2=CC=C(F)C=C2C)=C(C=CC(N3C4=C(F)C=CC=C4F)=O)C3=N1)NC#N
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
SB 706504 Related Classifications
HY-108644 Related Classifications
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