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Cat. No.: HY-152222

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SPR38

SPR38 is a potent SARS-CoV-2 main protease inhibitor, with a K_i of 0.260 μM. SPR38 also inhibits hCatL and hCatB, with K_i values of 1.92 μM and 11.1 μM, respectively.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

화학식: C₂₄H₃₃N₃O₅
분자량:443.54

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

SPR38 Chemical Structure

사이즈

가격

재고

수량

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

SPR38 is a potent SARS-CoV-2 main protease inhibitor, with a K_i of 0.260 μM. SPR38 also inhibits hCatL and hCatB, with K_i values of 1.92 μM and 11.1 μM, respectively^[1].

IC₅₀ & Target

cathepsin L

1.92 ± 0.1 μM (IC₅₀)

Cathepsin B

11.1 ± 1.2 μM (IC₅₀)

All Cathepsin Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
Huh-7	CC₅₀	60.9 μM Compound: SPR38	Cytotoxicity against human Huh-7 cells overexpressing human ACE2 assessed as reduction in cell viability incubated for 24 hrs by MTT assay Cytotoxicity against human Huh-7 cells overexpressing human ACE2 assessed as reduction in cell viability incubated for 24 hrs by MTT assay	[PMID: 36549112]

In Vitro

SPR38 shows no inhibition at 100 μM against SARS-CoV-2 papain-like protease (PL^pro), which plays a crucial role in processing viral polyproteins^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

분자량 443.54
화학식 C₂₄H₃₃N₃O₅
SMILES

O=C(OCC1=CC=CC=C1)N[C@@H](CCCC)C(N[C@H](/C=C/C(C)=O)C[C@H]2C(NCC2)=O)=O
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Previti S, et al. Structure-based lead optimization of peptide-based vinyl methyl ketones as SARS-CoV-2 main protease inhibitors. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

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Other size

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Amount: USD 0.00

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References

상품명:
Cat. No.:
수량:
MCE Japan Authorized Agent:

상품명:
CAS No.:
Species:
Purity:
수량:

SPR38

All Cathepsin Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

SPR38 Related Classifications

HY-152222 Related Classifications