Cat. No.: HY-163469

SRC-3-IN-2

고객리뷰

Based on 1 Customer Validation

SRC-3-IN-2 (SI-12 6c)is an orally active steroid receptor coactivator 3 (SRC-3) inhibitor. SRC-3-IN-2 has antitumor activity.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

Purity: 96.32%
CAS No.: 3074959-44-4
화학식: C₁₅H₁₂F₃N₅
분자량:319.28

보관:

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

SRC-3-IN-2 Chemical Structure

CAS No.: 3074959-44-4

사이즈

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
용액&용해도
- In Vitro
순도&문서
References
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

SRC-3-IN-2 (SI-12 6c)is an orally active steroid receptor coactivator 3 (SRC-3) inhibitor. SRC-3-IN-2 has antitumor activity^[1].

All Src Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
BT-474	IC₅₀	0.8 nM Compound: SI-12 (6c)	Cytotoxicity against human BT-474 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay Cytotoxicity against human BT-474 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay	[PMID: 38551814]
Hepatocyte	IC₅₀	>1000 nM Compound: SI-12 (6c)	Cytotoxicity against CD-1 mouse Primary hepatocyte assessed as inhibition of cell growth incubated for 72 hrs by MTT assay Cytotoxicity against CD-1 mouse Primary hepatocyte assessed as inhibition of cell growth incubated for 72 hrs by MTT assay	[PMID: 38551814]
HPAC	IC₅₀	26 nM Compound: SI-12 (6c)	Cytotoxicity against human HPAC cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay Cytotoxicity against human HPAC cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay	[PMID: 38551814]
LNCaP	IC₅₀	25 nM Compound: SI-12 (6c)	Cytotoxicity against human LNCaP cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay Cytotoxicity against human LNCaP cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay	[PMID: 38551814]
MCF7	IC₅₀	3.4 nM Compound: SI-12 (6c)	Cytotoxicity against human MCF7 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay Cytotoxicity against human MCF7 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay	[PMID: 38551814]
MDA-MB-468	IC₅₀	15 nM Compound: SI-12 (6c)	Cytotoxicity against human MDA-MB-468 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay Cytotoxicity against human MDA-MB-468 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay	[PMID: 38551814]
PANC-1	IC₅₀	119 nM Compound: SI-12 (6c)	Cytotoxicity against SiRNA mediated SRC-3.2 knockdown human PANC-1 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay Cytotoxicity against SiRNA mediated SRC-3.2 knockdown human PANC-1 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay	[PMID: 38551814]
PANC-1	IC₅₀	147 nM Compound: SI-12 (6c)	Cytotoxicity against SiRNA mediated SRC-3.1 knockdown human PANC-1 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay Cytotoxicity against SiRNA mediated SRC-3.1 knockdown human PANC-1 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay	[PMID: 38551814]
PANC-1	IC₅₀	25.2 nM Compound: SI-12 (6c)	Cytotoxicity against human PANC-1 cells mediated with siRNA control assessed as inhibition of cell growth incubated for 72 hrs by MTT assay Cytotoxicity against human PANC-1 cells mediated with siRNA control assessed as inhibition of cell growth incubated for 72 hrs by MTT assay	[PMID: 38551814]
PANC-1	IC₅₀	29 nM Compound: SI-12 (6c)	Cytotoxicity against human PANC-1 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay Cytotoxicity against human PANC-1 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay	[PMID: 38551814]

In Vitro

SRC-3-IN-2 IC₅₀ value of MCF7 cell is 3.4 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Pharmacokinetic Analysis in CD-1 mice Model^[1]

Route	Dose (mg/kg)	AUC_last (ng·h/mL)	t_1/2 (h)	T_max (h)	C_max (ng/mL)	Cl_obs (mL·min/kg)	F (%)
i.v.	1	737	22.5	0.033	1066	22	/
p.o.	10	1719	14.3	0.25	217	/	24.6

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 3074959-44-4
Appearance Solid
분자량 319.28
화학식 C₁₅H₁₂F₃N₅
Color Purple to purplish red
SMILES

CN1C2=CC(F)=C(F)C=C2N/C1=N\N=C(C3=CC=C(C=N3)F)/C
선적

Room temperature in continental US; may vary elsewhere.
보관

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

용액&용해도

In Vitro:

DMSO : 25 mg/mL (78.30 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

3.1320 mL

15.6602 mL

31.3205 mL

5 mM

0.6264 mL

3.1320 mL

6.2641 mL

10 mM

0.3132 mL

1.5660 mL

3.1320 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Lu D, et al. Lead Compound Development of SRC-3 Inhibitors with Improved Pharmacokinetic Properties and Anticancer Efficacy. J Med Chem. 2024 Mar 29. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	3.1320 mL	15.6602 mL	31.3205 mL	78.3012 mL
	5 mM	0.6264 mL	3.1320 mL	6.2641 mL	15.6602 mL
	10 mM	0.3132 mL	1.5660 mL	3.1320 mL	7.8301 mL
	15 mM	0.2088 mL	1.0440 mL	2.0880 mL	5.2201 mL
	20 mM	0.1566 mL	0.7830 mL	1.5660 mL	3.9151 mL
	25 mM	0.1253 mL	0.6264 mL	1.2528 mL	3.1320 mL
	30 mM	0.1044 mL	0.5220 mL	1.0440 mL	2.6100 mL
	40 mM	0.0783 mL	0.3915 mL	0.7830 mL	1.9575 mL
	50 mM	0.0626 mL	0.3132 mL	0.6264 mL	1.5660 mL
	60 mM	0.0522 mL	0.2610 mL	0.5220 mL	1.3050 mL

Keywords

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SRC-3-IN-2

Kinase Inhibitor Library

Protein Tyrosine Kinase Compound Library

Anti-Cancer Compound Library

Reprogramming Compound Library

Orally Active Compound Library

Anti-Pancreatic Cancer Compound Library

Angiogenesis-Related Compound Library

Anti-Prostate Cancer Compound Library

Anti-Pulmonary Fibrosis Compound Library

Pain-Related Compound Library

Membrane Protein-targeted Compound Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Bioactive Compound Library

Protein Kinase Compound Library

High-Throughput Bioactive Compound Library

All Src Isoforms

Biological Activity

Chemical Information

용액&용해도

순도&문서

References

Help & FAQs

Complete Stock Solution Preparation Table

SRC-3-IN-2

Kinase Inhibitor Library

Protein Tyrosine Kinase Compound Library

Anti-Cancer Compound Library

Reprogramming Compound Library

Orally Active Compound Library

Anti-Pancreatic Cancer Compound Library

Angiogenesis-Related Compound Library

Anti-Prostate Cancer Compound Library

Anti-Pulmonary Fibrosis Compound Library

Pain-Related Compound Library

Membrane Protein-targeted Compound Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Bioactive Compound Library

Protein Kinase Compound Library

High-Throughput Bioactive Compound Library

All Src Isoforms

Biological Activity

Chemical Information

용액&용해도

순도&문서

References

Help & FAQs

Complete Stock Solution Preparation Table

SRC-3-IN-2 Related Classifications

HY-163469 Related Classifications