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Cat. No.: HY-136094

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SRT3657

SRT3657 is a brain-permeable activator of SIRT1, with neuroprotective effect.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

CAS No.: 1383551-17-4
화학식: C₄₀H₅₄N₈O₆S
분자량:774.97

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

SRT3657 Chemical Structure

CAS No.: 1383551-17-4

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vivo
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

SRT3657 is a brain-permeable activator of SIRT1, with neuroprotective effect^[1].

IC₅₀ & Target

SIRT1^[1]

All Sirtuin Isoforms :

In Vivo

SRT3657 (30 mg/kg; i.g.; daily; for 6 weeks) activates SIRT1 in CK-p25 mice^[1].
SRT3657 treatment prevents synaptic and neuronal loss and effectively rescues against neurodegeneration-driven memory impairments^[1].
SRT3657 recapitulates the neuroprotective potential of caloric restriction (CR)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Adult double-transgenic CK-p25 mice (3-month-old)^[1]
Dosage:

30 mg/kg
Administration:

Oral gavage, daily, for 6 weeks
Result:

Significantly upregulated the activity of SIRT1 in hippocampal extracts of CK-p25 animals.

Chemical Information

CAS No. 1383551-17-4
분자량 774.97
화학식 C₄₀H₅₄N₈O₆S
SMILES

O=C(N1CCC(OCC2=CN=C(SC(C3=CC=CC=C3NC(C4=NC(CCCC)=NC(NCCN(C(OC(C)(C)C)=O)C)=C4)=O)=N5)C5=C2)CC1)OC(C)(C)C
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Gräff J, et al. A dietary regimen of caloric restriction or pharmacological activation of SIRT1 to delay the onset of neurodegeneration. J Neurosci. 2013 May 22;33(21):8951-60. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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Other size

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Amount: USD 0.00

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vivo
Chemical Information
순도&문서
References

상품명:
Cat. No.:
수량:
MCE Japan Authorized Agent:

상품명:
CAS No.:
Species:
Purity:
수량:

SRT3657

All Sirtuin Isoforms

Biological Activity

제품 설명

IC50 & Target

In Vivo

Chemical Information

순도&문서

References

Calculators

Help & FAQs

SRT3657 Related Classifications

HY-136094 Related Classifications

Bioz

Keywords

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