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Cat. No.: HY-169007

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STAT3-IN-34

STAT3-IN-34 (Compound 15E) is an inhibitor for STAT3, and inhibits the nuclear translocation and transcriptional regulator activity of STAT3. STAT3-IN-34 inhibits the proliferation of cell HaCaT with IC₅₀ of 0.008 μM. STAT3-IN-34 inhibits IL-17A expression and ameliorates Imiquimod (HY-B0180)-induced psoriasis in mice.

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화학식: C₁₉H₁₆N₂O₄S
분자량:368.41

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

STAT3-IN-34 Chemical Structure

사이즈

가격

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수량

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- Cellular Effect
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

All STAT Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
HaCaT	IC₅₀	0.008 μM Compound: 15e	Antiproliferative activity against human HaCaT cells incubated for 48 hrs by MTT assay Antiproliferative activity against human HaCaT cells incubated for 48 hrs by MTT assay	[PMID: 39151117]

Chemical Information

분자량 368.41
화학식 C₁₉H₁₆N₂O₄S
SMILES

CN(CCOC1=CC=C(C=C1)C2=NOC3=C2C(C4=C(C3=O)C=CS4)=O)C
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Chen L, et al., Design, Synthesis, and Biological Activity of Novel Quinone Derivatives as Potent STAT3 Inhibitors for Psoriasis Treatment. J Med Chem. 2024 Aug 16. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

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Molecular Weight Molecular Weight

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Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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Amount: USD 0.00

Biological Activity
- 제품 설명
Chemical Information
순도&문서
References

상품명:
Cat. No.:
수량:
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STAT3-IN-34

All STAT Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

STAT3-IN-34 Related Classifications

HY-169007 Related Classifications