T2384
T2384 is a peroxisome proliferator-activated receptor γ (PPARγ) ligand. T2384 also is an orally active antidiabetic agent. T2384 reduces the fasting plasma glucose levels and plasma insulin levels.
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- CAS No.: 315222-83-4
- 화학식: C20H10Cl3F3N2O2S3
- 분자량:569.85
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Protocol
- 순도&문서
- References
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Help & FAQs
Biological Activity
제품 설명
IC50 & Target
[1]|
PPARγ |
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:5-7 weeks, KKAy male mice (diabetes model)[1]
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Dosage:30, 100 mg/kg
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Administration:Diet; 4 days
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Result:Effectively reduced the fasting plasma glucose levels and plasma insulin levels, the food consumption was not significantly affected.
Chemical Information
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CAS No. 315222-83-4
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분자량 569.85
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화학식 C20H10Cl3F3N2O2S3
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SMILES
O=S(C1=CC=C(C=C1Cl)C(F)(F)F)(NC2=CC=C(C(Cl)=C2)SC3=NC4=CC(Cl)=CC=C4S3)=O
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocol
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Research Protocol for Endocrine Diseases
Endocrine diseases often arise from disrupted hormone production, hormone signaling, or target-tissue responsiveness; for diabetes-focused endocrine disease models, insulin signaling regulates glucose uptake, hepatic glucose output, lipid metabolism, and β-cell compensation. Type 2 diabetes develops through interacting defects in insulin resistance, β-cell dysfunction, adipose inflammation, hepatic glucose overproduction, altered incretin signaling, and ectopic lipid metabolism. A major unresolved question is whether endocrine dysfunction is driven primarily by target-tissue insulin resistance, intrinsic β-cell failure, immune/inflammatory stress, or combined multi-organ failure that differs by disease stage.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
T2384 Related Classifications
HY-122083 Related Classifications
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