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Cat. No.: HY-183522

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Thiocoumarin

Thiocoumarin is a carbonic anhydrase (CA) inhibitor, with K_i values of 0.047 μM, 0.042 μM, and 0.1 μM against hCA IX, mCA XIII, and hCA I, respectively; its K_i values against hCA IV, mCA XV, hCA II, hCA VA, hCA VB, hCA VI, hCA VII, hCA XII, and hCA XIV are 4.1, 4.8, 6.2, 8.4, 7.5, 8.8, 7.3, 8.7, and 7.4 μM, respectively. As a photocage molecule, Thiocoumarin undergoes photolysis upon illumination to release the caged molecule, and it exhibits red-shifted absorption properties and rapid photolysis kinetics. Thiocoumarin can be used in cancer-related research.

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CAS No.: 3986-98-9
화학식: C₉H₆OS
분자량:162.21

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Thiocoumarin Chemical Structure

CAS No.: 3986-98-9

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
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- In Vitro
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Biological Activity

제품 설명

All Carbonic Anhydrase Isoforms :

In Vitro

Thiocoumarin-caged ATP is rapidly and cleanly uncaged to release ATP upon irradiation with 490 nm light (full release within 4 min at all tested intensities) or 400 nm light (full release within 30 s at 50% intensity) at a concentration of 1 mM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 3986-98-9
분자량 162.21
화학식 C₉H₆OS
SMILES

S=C1OC2=C(C=C1)C=CC=C2
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Ma J, et al. Thiocoumarin Caged Nucleotides: Synthetic Access and Their Photophysical Properties. Molecules (Basel, Switzerland). 2020 Nov 15;25(22):5325. [Content Brief]

[2]. Maresca A, et al. Deciphering the mechanism of carbonic anhydrase inhibition with coumarins and thiocoumarins. Journal of medicinal chemistry. 2010 Jan 14;53(1):335-44. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
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Thiocoumarin

All Carbonic Anhydrase Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

Thiocoumarin Related Classifications

HY-183522 Related Classifications