country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-14826

Copy Link Print Information

Tilivapram

(Synonyms: AVE8112)

고객리뷰

Based on 1 Customer Validation

Tilivapram (AVE8112) is an orally active PDE4 inhibitor with procognitive effects. Tilivapram exhibits in vivo efficacy and improves processing speed and psychomotor speed. Oral administration of tilivapram may induce dose-related adverse reactions such as nausea and dizziness, but transdermal delivery enables slow, controlled elevation of plasma concentrations, thereby significantly reducing gastrointestinal discomfort and dizziness. Tilivapram is applicable to research related to neuropsychiatric disorders.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

Purity: 99.96%
CAS No.: 166741-91-9
화학식: C₁₆H₁₅Cl₂N₃O₄
분자량:384.21

보관:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

Tilivapram Chemical Structure

CAS No.: 166741-91-9

사이즈

가격

재고

수량

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
- Clinical Trial
Chemical Information
용액&용해도
- In Vitro
순도&문서
References
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target

PDE4

All Phosphodiesterase (PDE) Isoforms :

In Vitro

Tilivapram has a wide therapeutic window within the dose range of 0.5 mg to 1.5 mg. Tilivapram modulates electroencephalogram features (such as reducing resting-state θ power, enhancing θ coherence and γ phase-locking during stimulus processing) and mismatch negativity^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Chemical Information

CAS No. 166741-91-9
Appearance Solid
분자량 384.21
화학식 C₁₆H₁₅Cl₂N₃O₄
Color Off-white to light yellow
SMILES

ClC1=C(NC(C2=NC=C(OC)C(OCC3CC3)=C2)=O)C(Cl)=C[N+]([O-])=C1
Synonyms

AVE8112
선적

Room temperature in continental US; may vary elsewhere.

보관

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

용액&용해도

In Vitro:

DMSO : 50 mg/mL (130.14 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.6027 mL

13.0137 mL

26.0274 mL

5 mM

0.5205 mL

2.6027 mL

5.2055 mL

10 mM

0.2603 mL

1.3014 mL

2.6027 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Korean - KR (254 KB)
- Portuguese - PT (254 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Amit Etkin, et al Treatment of neuropsychiatric disorders with tilivapram. WO2025080415A1.

[2]. Bloom B. Contribution of Not-for-Profit Organizations to Drug Repurposing[M]//Drug Repositioning. CRC Press, 2017: 41-59.

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.6027 mL	13.0137 mL	26.0274 mL	65.0686 mL
	5 mM	0.5205 mL	2.6027 mL	5.2055 mL	13.0137 mL
	10 mM	0.2603 mL	1.3014 mL	2.6027 mL	6.5069 mL
	15 mM	0.1735 mL	0.8676 mL	1.7352 mL	4.3379 mL
	20 mM	0.1301 mL	0.6507 mL	1.3014 mL	3.2534 mL
	25 mM	0.1041 mL	0.5205 mL	1.0411 mL	2.6027 mL
	30 mM	0.0868 mL	0.4338 mL	0.8676 mL	2.1690 mL
	40 mM	0.0651 mL	0.3253 mL	0.6507 mL	1.6267 mL
	50 mM	0.0521 mL	0.2603 mL	0.5205 mL	1.3014 mL
	60 mM	0.0434 mL	0.2169 mL	0.4338 mL	1.0845 mL
	80 mM	0.0325 mL	0.1627 mL	0.3253 mL	0.8134 mL
	100 mM	0.0260 mL	0.1301 mL	0.2603 mL	0.6507 mL

Keywords

MOQ

Minimum order quantity

100 mg

견적 받기 해외재고보유

Other size

견적 받기

Amount: USD 0.00

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
- Clinical Trial
Chemical Information
용액&용해도
- In Vitro
순도&문서
References

상품명:
Cat. No.:
수량:
MCE Japan Authorized Agent:

상품명:
CAS No.:
Species:
Purity:
수량:

Tilivapram

Metabolism/Protease Compound Library

Clinical Compound Library

Orally Active Compound Library

Anti-Alzheimer's Disease Compound Library

Neurodegenerative Disease-related Compound Library

Anti-Colorectal Cancer Compound Library

Antidepressant Compound Library

Metabolic Enzyme Compound Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Clinical Compound Library Plus

Bioactive Compound Library

High-Throughput Bioactive Compound Library

All Phosphodiesterase (PDE) Isoforms

Biological Activity

Chemical Information

용액&용해도

순도&문서

References

Help & FAQs

Complete Stock Solution Preparation Table

Tilivapram

Metabolism/Protease Compound Library

Clinical Compound Library

Orally Active Compound Library

Anti-Alzheimer's Disease Compound Library

Neurodegenerative Disease-related Compound Library

Anti-Colorectal Cancer Compound Library

Antidepressant Compound Library

Metabolic Enzyme Compound Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Clinical Compound Library Plus

Bioactive Compound Library

High-Throughput Bioactive Compound Library

All Phosphodiesterase (PDE) Isoforms

Biological Activity

Chemical Information

용액&용해도

순도&문서

References

Help & FAQs

Complete Stock Solution Preparation Table

Tilivapram Related Classifications

HY-14826 Related Classifications