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Cat. No.: HY-187211

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TYK2 activator-2

TYK2 activator-2 (Compound 6g) is a selective TYK2 activator and JAK3 inhibitor, with an EC₅₀ of 0.21 μM against TYK2 and an IC₅₀ of 1.2 μM against JAK3. TYK2 activator-2 destabilizes the JH2-JH1 autoinhibitory complex of TYK2, enhances the catalytic activity of TYK2, and inhibits the JH1 kinase domain activity of JAK3. TYK2 activator-2 can be used in cancer-related research.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

화학식: C₂₈H₂₄FN₅O₂
분자량:481.52

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

TYK2 activator-2 Chemical Structure

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
Chemical Information
Protocol (1)
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target

^[1]

Tyk2

0.21 μM (EC₅₀)

JAK3

1.2 μM (IC₅₀)

All JAK Isoforms :

Chemical Information

분자량 481.52
화학식 C₂₈H₂₄FN₅O₂
SMILES

COC1=C(C#CC2=CC=CC=C2)C=CC=C1NC3=CC(NC4=CC(C)=C(F)C=N4)=NC=C3C(NC)=O
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocol

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Matsumoto H, et al. Identification of TYK2 activators. Part 2: Optimization of terminal alkyne substituents to enhance activation potency. Bioorganic & medicinal chemistry letters. 2026 Jul 07;140:130728. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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Other size

견적 받기

Amount: USD 0.00

Biological Activity
- 제품 설명
- IC₅₀ & Target
Chemical Information
Protocol
순도&문서
References

상품명:
Cat. No.:
수량:
MCE Japan Authorized Agent:

상품명:
CAS No.:
Species:
Purity:
수량:

TYK2 activator-2

All JAK Isoforms

Biological Activity

제품 설명

IC50 & Target

Chemical Information

Protocol

순도&문서

References

Calculators

Help & FAQs

TYK2 activator-2 Related Classifications

HY-187211 Related Classifications

Bioz

Keywords

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