TZD18
TZD18 is a potent and orally active PPARα and PPARγ dual agonist with IC50 values of 0.028, 0.057, >10 µM for PPARα, PPARγ, PPARδ, respectively. TZD18 reduces plasma levels of both glucose and triglycerides in diabetic mice. TZD18 has the potential for the research of type 2 diabetes.
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- CAS No.: 228577-00-2
- 화학식: C27H27NO5S
- 분자량:477.57
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
Biological Activity
제품 설명
IC50 & Target
[1]|
hPPARα 0.028 μM (IC50) |
hPPARγ 0.057 μM (IC50) |
PPARδ >10 μM (IC50) |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
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| COS-1 | EC50 |
>3 μM
Compound: 12
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In vitro transactivation of human Peroxisome proliferator activated receptor delta measured in PPAR-GAL4 chimeric COS-1 cells
In vitro transactivation of human Peroxisome proliferator activated receptor delta measured in PPAR-GAL4 chimeric COS-1 cells
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[PMID: 12873517] |
| COS-1 | EC50 |
0.014 μM
Compound: 12
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In vitro transactivation of human peroxisome proliferator activated receptor gamma measured in PPAR-GAL4 chimeric COS-1 cells
In vitro transactivation of human peroxisome proliferator activated receptor gamma measured in PPAR-GAL4 chimeric COS-1 cells
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[PMID: 12873517] |
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:12-13 weeks, Male db/db and nondiabetic db/+ (lean) mice (type 2 diabetes) [1]
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Dosage:3, 10 mg/kg
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Administration:P.o.; daily for 11 days
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Result:Reduced hyperglycemia and plasma triglyceride levels.
Chemical Information
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CAS No. 228577-00-2
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분자량 477.57
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화학식 C27H27NO5S
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SMILES
O=C(SC1C2=CC=CC(OCCCOC3=CC=C(C=C3CCC)OC4=CC=CC=C4)=C2)NC1=O
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
TZD18 Related Classifications
HY-121798 Related Classifications
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