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Cat. No.: HY-141895

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Vps34-IN-3

Vps34-IN-3 is a potent, selective, and orally bioavailable VPS34 kinase inhibitor.

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CAS No.: 2770104-92-0
화학식: C₁₄H₂₀N₄O₂
분자량:276.33

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

Vps34-IN-3 Chemical Structure

CAS No.: 2770104-92-0

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- Cellular Effect
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

Vps34-IN-3 is a potent, selective, and orally bioavailable VPS34 kinase inhibitor.

All PI3K Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
U2OS	IC₅₀	200 nM Compound: 5	Inhibition of autophagy in GFP-FYVE tagged human U2OS cells assessed as decrease in PI3P-mediated GFP-puncta formation by Hoechst 33258 staining based fluorescence microscopic analysis Inhibition of autophagy in GFP-FYVE tagged human U2OS cells assessed as decrease in PI3P-mediated GFP-puncta formation by Hoechst 33258 staining based fluorescence microscopic analysis	[PMID: 34779204]

Chemical Information

CAS No. 2770104-92-0
분자량 276.33
화학식 C₁₄H₂₀N₄O₂
SMILES

C[C@H]1N(C2=NN([C@H](CCC3)[C@H]3NC4=O)C4=C2)CCOC1
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Hu DX, et al. Structure-Based Design of Potent, Selective, and Orally Bioavailable VPS34 Kinase Inhibitors. J Med Chem. 2021 Nov 15. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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Biological Activity
- 제품 설명
Chemical Information
순도&문서
References

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Vps34-IN-3

All PI3K Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

Vps34-IN-3 Related Classifications

HY-141895 Related Classifications