WJM-715
WJM-715 is an antimalarial agent with an EC50 of 0.015 μM by trageting STAR-related lipid transfer protein (PfSTART1) with a KD of 14 nM.
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- 화학식: C19H22Cl2N4O4S
- 분자량:473.37
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
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Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HepG2 | EC50 |
>40 μM
Compound: 19b; WJM-715
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Cytotoxicity against human HepG2 cells assessed as reduction in cell viability incubated for 48 hrs by Cell Titer-Glo assay
Cytotoxicity against human HepG2 cells assessed as reduction in cell viability incubated for 48 hrs by Cell Titer-Glo assay
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[PMID: 38554474] |
WJM-715 improves the aqueous solubility at pH 7.4 to 60 μM and the metabolic stability in rats hepatocytes to 68 μL/min/106cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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분자량 473.37
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화학식 C19H22Cl2N4O4S
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SMILES
O=S(N1CCOCC1)(C2=C(Cl)C=CC(NC(C)(C)C(NC3=CN=CC(Cl)=C3)=O)=C2)=O
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
WJM-715 Related Classifications
HY-161384 Related Classifications
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