2. Cytoskeleton
  3. Integrin
  4. Lefradafiban

Lefradafiban is an orally active glycoprotein IIb/IIIa receptor antagonist. Lefradafiban can be metabolized to its active form, Fradafiban, a non-peptide GP IIb/IIIa receptor antagonist.

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Lefradafiban

Lefradafiban Chemical Structure

CAS No. : 149503-79-7

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Based on 1 publication(s) in Google Scholar

Lefradafiban Related Antibodies

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αvβ1 αvβ3 αvβ5 αvβ6 αvβ8 α5β1 α1β1 α2β1 α4β1 α9β1 αIIbβ3 α4β7 αLβ2

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Description

Lefradafiban is an orally active glycoprotein IIb/IIIa receptor antagonist. Lefradafiban can be metabolized to its active form, Fradafiban, a non-peptide GP IIb/IIIa receptor antagonist[1].

Clinical Trial
Molecular Weight

439.46

Formula

C23H25N3O6
CAS No.
Appearance

Solid

Color

white

SMILES

N=C(C(C=C1)=CC=C1C(C=C2)=CC=C2OC[C@H]3NC([C@H](CC(OC)=O)C3)=O)NC(OC)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 45 mg/mL (102.40 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2755 mL 11.3776 mL 22.7552 mL
5 mM 0.4551 mL 2.2755 mL 4.5510 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.2755 mL 11.3776 mL 22.7552 mL 56.8880 mL
5 mM 0.4551 mL 2.2755 mL 4.5510 mL 11.3776 mL
10 mM 0.2276 mL 1.1378 mL 2.2755 mL 5.6888 mL
15 mM 0.1517 mL 0.7585 mL 1.5170 mL 3.7925 mL
20 mM 0.1138 mL 0.5689 mL 1.1378 mL 2.8444 mL
25 mM 0.0910 mL 0.4551 mL 0.9102 mL 2.2755 mL
30 mM 0.0759 mL 0.3793 mL 0.7585 mL 1.8963 mL
40 mM 0.0569 mL 0.2844 mL 0.5689 mL 1.4222 mL
50 mM 0.0455 mL 0.2276 mL 0.4551 mL 1.1378 mL
60 mM 0.0379 mL 0.1896 mL 0.3793 mL 0.9481 mL
80 mM 0.0284 mL 0.1422 mL 0.2844 mL 0.7111 mL
100 mM 0.0228 mL 0.1138 mL 0.2276 mL 0.5689 mL
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Lefradafiban Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Lefradafiban149503-79-7IntegrinGP IIb/IIIa receptorfradafibannon-peptideInhibitorinhibitorinhibit

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