MTR-106
Based on 1 Customer Validation
MTR-106 is a potent and orally active G-quadruplex stabilizer and RNA polymerase I inhibitor. MTR-106 induces apoptosis and inhibits cell growth. MTR-106 can be used in research of cancer.
For research use only. We do not sell to patients.
- Purity: 98.21%
- CAS No.: 1639357-93-9
- Formula: C28H27N7O2S
- Molecular Weight:525.62
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Apoptosis Compound Library
HY-L003
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Cell Cycle/DNA Damage Compound Library
HY-L004
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Anti-Cancer Compound Library
HY-L025
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Anti-Aging Compound Library
HY-L034
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Orally Active Compound Library
HY-L061
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Cell Death Library
HY-L162
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Bioactive Compound Library Max
HY-L181
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MCE Bioactive Compound Library
HY-L001V
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Bioactive Compound Library
HY-L001
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Non-Alcoholic Fatty Liver Disease (NAFLD) Compound Library
HY-L199
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High-Throughput Bioactive Compound Library
HY-L205
All DNA/RNA Synthesis Isoforms
More
Biological Activity
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RNA Polymerase |
MTR-106 (0-100 μM; 7 d) has antitumor activity in both HR-deficient cells and PARPi-resistant cells[1].
MTR-106 (0-100 μM; 7 d) induces apoptosis, cell cycle arrest and DNA damage[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HR-deficient and PARPi-resistant cancer cells
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Concentration:0-100 μM
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Incubation Time:7 days
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Result:Inhibited the viability of HR-deficient cells and PARPi-resistant cells in a dose-dependent nanner.
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Cell Line:Capan-1 cells
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Concentration:0.1, 0.3, and 1 μM
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Incubation Time:24 hours
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Result:Increased in cells in G2/M, accompanied by a reduction in cell numbers in G1.
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Cell Line:Capan-1 cells
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Concentration:1, 5, and 10 μM
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Incubation Time:24 hours
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Result:Increased the cleaved caspases 3, 7, and 9 and cleaved PARP in a dose-dependent manner.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:BRCA-deficient and PARPi-resistant xenografts in nude mice[1]
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Dosage:10, 20, and 30 mg/kg
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Administration:oral administration; twice a week, for 29 days
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Result:Inhibited tumor growth in a dose-dependent manner.
Chemical Information
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CAS No. 1639357-93-9
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Appearance Solid
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Molecular Weight 525.62
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Formula C28H27N7O2S
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Color White to off-white
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SMILES
CC1=CN=C(C=N1)CNC(C2=C3N(C4=CC=CC=C4S3)C5=NC(N6C[C@]7([H])[C@](CN(C7)C)([H])C6)=CC=C5C2=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 2 mg/mL (3.81 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (278 KB)
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SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Korean - KR (254 KB)
- Portuguese - PT (254 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.9025 mL | 9.5126 mL | 19.0252 mL | 47.5629 mL |
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