MTR-106
Based on 1 Customer Validation
MTR-106 is a potent and orally active G-quadruplex stabilizer and RNA polymerase I inhibitor. MTR-106 induces apoptosis and inhibits cell growth. MTR-106 can be used in research of cancer.
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- Pureté: 98.21%
- CAS No.: 1639357-93-9
- Formule: C28H27N7O2S
- Masse moléculaire:525.62
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Stockage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
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Activité biologique
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RNA Polymerase |
MTR-106 (0-100 μM; 7 d) has antitumor activity in both HR-deficient cells and PARPi-resistant cells[1].
MTR-106 (0-100 μM; 7 d) induces apoptosis, cell cycle arrest and DNA damage[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HR-deficient and PARPi-resistant cancer cells
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Concentration:0-100 μM
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Incubation Time:7 days
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Result:Inhibited the viability of HR-deficient cells and PARPi-resistant cells in a dose-dependent nanner.
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Cell Line:Capan-1 cells
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Concentration:0.1, 0.3, and 1 μM
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Incubation Time:24 hours
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Result:Increased in cells in G2/M, accompanied by a reduction in cell numbers in G1.
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Cell Line:Capan-1 cells
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Concentration:1, 5, and 10 μM
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Incubation Time:24 hours
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Result:Increased the cleaved caspases 3, 7, and 9 and cleaved PARP in a dose-dependent manner.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:BRCA-deficient and PARPi-resistant xenografts in nude mice[1]
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Dosage:10, 20, and 30 mg/kg
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Administration:oral administration; twice a week, for 29 days
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Result:Inhibited tumor growth in a dose-dependent manner.
Chemical Information
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CAS No. 1639357-93-9
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Appearance Solid
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Masse moléculaire 525.62
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Formule C28H27N7O2S
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Color White to off-white
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SMILES
CC1=CN=C(C=N1)CNC(C2=C3N(C4=CC=CC=C4S3)C5=NC(N6C[C@]7([H])[C@](CN(C7)C)([H])C6)=CC=C5C2=O)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvant et solubilité
DMSO : 2 mg/mL (3.81 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureté et documentation
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Fiche technique (278 KB)
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SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Korean - KR (254 KB)
- Portuguese - PT (254 KB)
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Instruction de manipulation (2659 KB)
Références
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.9025 mL | 9.5126 mL | 19.0252 mL | 47.5629 mL |
MTR-106 Related Classifications
HY-148953 Related Classifications
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