2. Cell Cycle/DNA Damage Apoptosis
  3. G-quadruplex DNA/RNA Synthesis Apoptosis
  4. MTR-106

MTR-106 is a potent and orally active G-quadruplex stabilizer and RNA polymerase I inhibitor. MTR-106 induces apoptosis and inhibits cell growth. MTR-106 can be used in research of cancer.

For research use only. We do not sell to patients.

MTR-106 Chemical Structure

MTR-106 Chemical Structure

CAS No. : 1639357-93-9

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Based on 1 publication(s) in Google Scholar

MTR-106 Related Antibodies

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Description

MTR-106 is a potent and orally active G-quadruplex stabilizer and RNA polymerase I inhibitor. MTR-106 induces apoptosis and inhibits cell growth. MTR-106 can be used in research of cancer[1].

In Vitro

MTR-106 (0-100 μM; 7 d) has antitumor activity in both HR-deficient cells and PARPi-resistant cells[1].
MTR-106 (0-100 μM; 7 d) induces apoptosis, cell cycle arrest and DNA damage[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

MTR-106 Related Antibodies

Cell Viability Assay[1]

Cell Line: HR-deficient and PARPi-resistant cancer cells
Concentration: 0-100 μM
Incubation Time: 7 days
Result: Inhibited the viability of HR-deficient cells and PARPi-resistant cells in a dose-dependent nanner.

Cell Cycle Analysis[1]

Cell Line: Capan-1 cells
Concentration: 0.1, 0.3, and 1 μM
Incubation Time: 24 hours
Result: Increased in cells in G2/M, accompanied by a reduction in cell numbers in G1.

Western Blot Analysis[1]

Cell Line: Capan-1 cells
Concentration: 1, 5, and 10 μM
Incubation Time: 24 hours
Result: Increased the cleaved caspases 3, 7, and 9 and cleaved PARP in a dose-dependent manner.
In Vivo

MTR-106 (10-30 mg/kg; p.o.; twice a week, for 29 days) suppresses the tumor growth of BRCA-deficient and PARPi-resistant xenografts in nude mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: BRCA-deficient and PARPi-resistant xenografts in nude mice[1]
Dosage: 10, 20, and 30 mg/kg
Administration: oral administration; twice a week, for 29 days
Result: Inhibited tumor growth in a dose-dependent manner.
Molecular Weight

525.62

Formula

C28H27N7O2S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CC1=CN=C(C=N1)CNC(C2=C3N(C4=CC=CC=C4S3)C5=NC(N6C[C@]7([H])[C@](CN(C7)C)([H])C6)=CC=C5C2=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 2 mg/mL (3.81 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9025 mL 9.5126 mL 19.0252 mL
5 mM --- --- ---
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.9025 mL 9.5126 mL 19.0252 mL 47.5629 mL
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MTR-106 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MTR-1061639357-93-9MTR106MTR 106G-quadruplexDNA/RNA SynthesisApoptosisHR-deficient cellsPARPi-resistant cellscancerInhibitorinhibitorinhibit

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