Colivelin
Based on 92 publication(s) in Google Scholar
Colivelin is a brain penetrant neuroprotective peptide and a potent activator of STAT3, suppresses neuronal death by activating STAT3 in vitro. Colivelin exhibits long-term beneficial effects against neurotoxicity, Aβ deposition, neuronal apoptosis, and synaptic plasticity deficits in neurodegenerative disease. Colivelin has the potential for the treatment of alzheimer's disease and ischemic brain injury
For research use only. We do not sell to patients.
- Purity: 99.92%
- CAS No.: 867021-83-8
- Formula: C119H206N32O35
- Molecular Weight:2645.10
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Storage:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Publications Citing Use of MedChemExpress (MCE) Colivelin
More- Drug Resist Updat. 2025 Jul:81:101224. [Abstract]
- Nat Commun. 2021 Nov 25;12(1):6891. [Abstract]
- Sci Transl Med. 2021 Oct 6;13(614):eabg6428. [Abstract]
- J Adv Res. 2025 Mar 31:S2090-1232(25)00218-8. [Abstract]
- Exp Mol Med. 2026 Feb;58(1):178-198. [Abstract]
- J Nanobiotechnology. 2025 Mar 29;23(1):258. [Abstract]
- J Nanobiotechnology. 2024 Aug 24;22(1):509. [Abstract]
- J Nanobiotechnology. 2024 Jul 11;22(1):409. [Abstract]
- J Nanobiotechnology. 2024 Jun 19;22(1):345. [Abstract]
- Redox Biol. 2026 May:92:104137. [Abstract]
- Redox Biol. 2023 Dec:68:102956. [Abstract]
- J Hazard Mater. 2026 Feb 1:503:141124. [Abstract]
- Int J Biol Sci. 2025 Apr 28;21(7):3229-3246. [Abstract]
- Int J Biol Sci. 2023 Apr 2;19(7):2021-2033. [Abstract]
- Proc Natl Acad Sci U S A. 2022 Oct 11;119(41):e2122099119. [Abstract]
- Cell Commun Signal. 2021 Nov 16;19(1):115. [Abstract]
- Phytomedicine. 2026 Apr:153:157986. [Abstract]
- Phytomedicine. 2025 Sep 11:148:157257. [Abstract]
- Phytomedicine. 2024 Jul:129:155563. [Abstract]
- Phytomedicine. 2023 Jun:114:154799. [Abstract]
- Phytomedicine. 2023 Jan:109:154551. [Abstract]
- Free Radic Biol Med. 2024 Aug 28:S0891-5849(24)00630-0. [Abstract]
- J Transl Med. 2025 Oct 2;23(1):1043. [Abstract]
- J Transl Med. 2025 Jul 10;23(1):780. [Abstract]
- J Transl Med. 2025 May 27;23(1):593. [Abstract]
- J Transl Med. 2025 May 2;23(1):502. [Abstract]
- Biomed Pharmacother. 2020 Nov;131:110541. [Abstract]
- Chin Med J (Engl). 2026 May 5;139(9):1375-1387. [Abstract]
- Oncogene. 2017 Oct 12;36(41):5709-5721. [Abstract]
- Stem Cell Res Ther. 2025 May 5;16(1):227. [Abstract]
- Int J Nanomedicine. 2023 Nov 29:18:7095-7113. [Abstract]
- Phytother Res. 2026 May;40(5):2473-2490. [Abstract]
- J Agric Food Chem. 2025 Oct 22;73(42):27025-27037. [Abstract]
- J Agric Food Chem. 2025 Mar 5;73(9):5208-5222. [Abstract]
- J Agric Food Chem. 2021 Jul 21;69(28):7898-7909. [Abstract]
- Ecotoxicol Environ Saf. 2024 Aug 12:283:116857. [Abstract]
- J Ethnopharmacol. 2025 Oct 22:120772. [Abstract]
- J Ethnopharmacol. 2024 Sep 13:118829. [Abstract]
- Commun Biol. 2022 Dec 1;5(1):1316. [Abstract]
- Cancer Immunol Immunother. 2022 Jun 20. [Abstract]
- CNS Neurosci Ther. 2026 Mar;32(3):e70814. [Abstract]
- Inflammation. 2025 Feb;48(1):372-392. [Abstract]
- CNS Neurosci Ther. 2024 Apr;30(4):e14512. [Abstract]
- Int J Mol Sci. 2024 Mar 3;25(5):2950. [Abstract]
- Invest Ophthalmol Vis Sci. 2025 Dec 1;66(15):16. [Abstract]
- Int Immunopharmacol. 2024 Oct 18;143(Pt 2):113416. [Abstract]
- Int Immunopharmacol. 2024 May 30:133:112126. [Abstract]
- Inflamm Bowel Dis. 2023 Dec 5;29(12):1929-1940. [Abstract]
- J Ovarian Res. 2025 Dec 26;19(1):29. [Abstract]
- Biochim Biophys Acta Mol Basis Dis. 2024 Feb;1870(2):166979. [Abstract]
- Drug Dev Res. 2022 Dec;83(8):1831-1844. [Abstract]
- J Inflamm Res. 2025 Sep 8:18:12361-12377. [Abstract]
- J Inflamm Res. 2022 May 31:15:3187-3205. [Abstract]
- Antiviral Res. 2022 Jan:197:105228. [Abstract]
- Front Mol Biosci. 2021 Jun 18:8:654766. [Abstract]
- Sci Rep. 2025 Jun 5;15(1):19736. [Abstract]
- Sci Rep. 2025 May 2;15(1):15378. [Abstract]
- Oncol Rep. 2024 May;51(5):71. [Abstract]
- Aging. 2020 May 15;12(10):9066-9084. [Abstract]
- Neurochem Res. 2026 Mar 19;51(2):112. [Abstract]
- Cell Signal. 2026 Feb:138:112250. [Abstract]
- Brain Res Bull. 2024 Nov 13:219:111128. [Abstract]
- Cell Signal. 2020 Jul;71:109606. [Abstract]
- World J Stem Cells. 2024 Nov 26;16(11):906-925. [Abstract]
- Vascul Pharmacol. 2024 Jul 17:107411. [Abstract]
- Appl Biochem Biotechnol. 2026 Jan 15. [Abstract]
- Funct Integr Genomics. 2025 Mar 12;25(1):59. [Abstract]
- Mol Immunol. 2026 Feb:190:86-100. [Abstract]
- Mol Immunol. 2025 May:181:9-17. [Abstract]
- Burns. 2025 Jun 23;51(8):107586. [Abstract]
- Mol Biol Rep. 2024 Jan 22;51(1):176. [Abstract]
- Iran J Basic Med Sci. 2025;28(11):1563-1574. [Abstract]
- J Radiat Res Appl Sci. 2026 Feb 17.
- Tissue Cell. 2024 Nov 30:93:102645. [Abstract]
- J Nat Med. 2020 Jun;74(3):533-544. [Abstract]
- PeerJ. 2022 Sep 28;10:e14086. [Abstract]
- BMC Neurosci. 2025 Mar 7;26(1):21. [Abstract]
- Exp Ther Med. 2022 Apr;23(4):313. [Abstract]
- Biomol Biomed. 2024 Dec 11;25(1):82-93. [Abstract]
- Adv Rheumatol. 2024 Dec 18;64(1):88. [Abstract]
- Biochem Cell Biol. 2023 Feb 1;101(1):1-11. [Abstract]
- Biochem Cell Biol. 2022 Dec 1;100(6):473-484. [Abstract]
- J Surg Res. 2025 Jan 13:306:249-256. [Abstract]
- Int J Neurosci. 2021 Jan;131(1):15-24. [Abstract]
- Pol J Pathol. 2025;76(2):131-140. [Abstract]
- Preprints. 2025 Jun 24.
- SSRN. 2025 Jan 30.
- SSRN. 2024 Apr 7.
- J Physiol Investig. 2024 Jan 1;67(1):37-46. [Abstract]
- Frigid Zone Medicine. 20 May 2022.
- Ann Transl Med. 2020 Nov;8(21):1346. [Abstract]
- Research Square Preprint. 2020 Dec.
Customer Validation & Images
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In Vivo Efficacy Study
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WB
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ELISA
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Cell Proliferation/Viability Assay
Biological Activity
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STAT3 |
Amyloid-β |
Colivelin completely suppresses death induced by overexpressed FAD-causative genes and Aβ1-43 at a concentration of 100 fm, and keep its neuroprotective action at or above the levels of 1 nm[1].Colivelin-induced neuroprotection occurs via two neuroprotective pathways: one mediated by Ca2+/calmodulin-dependent protein kinase IV, triggered by ADNF, and one mediated by signal transducer and activator of transcription 3, triggered by HN[1].
Colivelin reverses caspase3, Bax and Bcl-2 expressions in HT22 cells medaited by rmMFG-E8 in the co-cultured cells under OGD condition[4].
Colivelin (50 μg/mL, 4 hours) significantly increases the p-STAT3 protein levels in BV-2 cells[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:BV-2 cells.
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Concentration:50 µg/mL.
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Incubation Time:4 hours.
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Result:Increased p-STAT3 levels.
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Cell Line:KYSE70 and TE8 cells.
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Concentration:0.5 μM.
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Incubation Time:1 hour (followed by CYT-Rx20 treatment)
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Result:Sgnificantly suppressed the viability in KYSE70 and TE8 cells.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:CD-1 mice[1]
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Dosage:10 pmol/3 μl
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Administration:Intracerebroventricular administration
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Result:Completely suppressed Aβ 25-35-mediated impairment in spatial working memory and increased the number of immunoreactive neurons.
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Animal Model:C57 mice[1]
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Dosage:1.4, 7, or 35 nM/0.21mL
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Administration:Intraperitoneal administration
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Result:Protected against cholinotoxin-induced amnesia in mice.
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Animal Model:Male C57BL/6 mice[3]
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Dosage:1 mg/kg
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Administration:Intraperitoneal administration
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Result:Protected against ischemic brain injury, and improves neurological outcomes
Chemical Information
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CAS No. 867021-83-8
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Appearance Solid
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Molecular Weight 2645.10
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Formula C119H206N32O35
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Color White to off-white
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Sequence
Ser-Ala-Leu-Leu-Arg-Ser-Ile-Pro-Ala-Pro-Ala-Gly-Ala-Ser-Arg-Leu-Leu-Leu-Leu-Thr-Gly-Glu-Ile-Asp-Leu-Pro
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Sequence Shortening
SALLRSIPAPAGASRLLLLTGEIDLP
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (92)
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Journal Impact Factor
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Most Recent
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Drug Resist Updat
DTX2 attenuates Lenvatinib-induced ferroptosis by suppressing docosahexaenoic acid biosynthesis through HSD17B4-dependent peroxisomal β-oxidation in hepatocellular carcinoma. [Abstract]2025 Jul:81:101224. PMID: 40058099 -
Nat Commun
STAT3 is critical for skeletal development and bone homeostasis by regulating osteogenesis. [Abstract]2021 Nov 25;12(1):6891. PMID: 34824272 -
Sci Transl Med
Targeting AKR1B1 inhibits glutathione de novo synthesis to overcome acquired resistance to EGFR-targeted therapy in lung cancer. [Abstract]2021 Oct 6;13(614):eabg6428. PMID: 34613810 -
J Adv Res
Metformin attenuates colitis via blocking STAT3 acetylation by reducing acetyl-CoA production. [Abstract]2025 Mar 31:S2090-1232(25)00218-8. PMID: 40174640 -
Exp Mol Med
Microglial CX3CR1 deficiency regulates the selective vulnerability of cone photoreceptors via STAT3/CCL-ACKR1 signaling in the mouse retina. [Abstract]2026 Feb;58(1):178-198. PMID: 41535549 -
J Nanobiotechnology
Single-cell multi-omics analysis reveals the mechanism of action of a novel antioxidant polyphenol nanoparticle loaded with STAT3 agonist in mediating cardiomyocyte ferroptosis to ameliorate age-related heart failure. [Abstract]2025 Mar 29;23(1):258. PMID: 40158134
Colivelin purchased from MedChemExpress. Usage Cited in: J Nanobiotechnology. 2025 Mar 29;23(1):258. [Abstract]
(A) Schematic diagram of the synthesis steps of PN@Col nanoparticles(61 mg (-)-Epigallocatechin Gallate (EGCG), 10 mg Glycine and 2 mg Colivelin);(B) Morphological features of PN (top) and PN@Col (bottom) observed using TEM (scale bar: 100 nm/200 nm);(C) Morphology of PN (top) and PN@Col (bottom) observed using SEM (scale bar: 5 μm/1 μm);
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J Nanobiotechnology
Circulating extracellular vesicle-derived miR-1299 disrupts hepatic glucose homeostasis by targeting the STAT3/FAM3A axis in gestational diabetes mellitus. [Abstract]2024 Aug 24;22(1):509. PMID: 39182087 -
J Nanobiotechnology
Targeting CSF1R in myeloid-derived suppressor cells: insights into its immunomodulatory functions in colorectal cancer and therapeutic implications. [Abstract]2024 Jul 11;22(1):409. PMID: 38992688
Colivelin purchased from MedChemExpress. Usage Cited in: J Nanobiotechnology. 2024 Jul 11;22(1):409. [Abstract]
Western blot analysis showed the expression levels of p-STAT3, CPT1A, and CPT1B in MDSCs after treatment with Colivelin (50 µg/mL; 4 h).
Colivelin purchased from MedChemExpress. Usage Cited in: J Nanobiotechnology. 2024 Jul 11;22(1):409. [Abstract]
ELISA measured the ability of Colivelin (50 µg/mL; 4 h) treatment to inhibit T cell proliferation and release IFNγ and GzmB.
Colivelin purchased from MedChemExpress. Usage Cited in: J Nanobiotechnology. 2024 Jul 11;22(1):409. [Abstract]
T cell proliferation assay measured the ability of Colivelin (50 µg/mL; 4 h) treatment to inhibit T cell proliferation and release IFNγ and GzmB.
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J Nanobiotechnology
Cartilage progenitor cells derived extracellular vesicles-based cell-free strategy for osteoarthritis treatment by efficient inflammation inhibition and extracellular matrix homeostasis restoration. [Abstract]2024 Jun 19;22(1):345. PMID: 38890638 -
Redox Biol
Astrocytic GSTM2-STAT3 interaction ameliorates the diabetes associated cognitive dysfunction via targeting mitochondrial defects and oxidative stress. [Abstract]2026 May:92:104137. PMID: 41916017 -
Redox Biol
MIOX inhibits autophagy to regulate the ROS -driven inhibition of STAT3/c-Myc-mediated epithelial-mesenchymal transition in clear cell renal cell carcinoma. [Abstract]2023 Dec:68:102956. PMID: 37977044 -
J Hazard Mater
Developmental nonylphenol exposure triggers GPER‑dependent microglial activation and subsequent neuronal injury. [Abstract]2026 Feb 1:503:141124. PMID: 41534279 -
Int J Biol Sci
Skeletal stem/progenitor cell-derived rather than osteoblast-derived IGF2 supports the development and homeostasis of skeletal system via STAT3. [Abstract]2025 Apr 28;21(7):3229-3246. PMID: 40384861 -
Int J Biol Sci
2023 Apr 2;19(7):2021-2033. PMID: 37151888 -
Proc Natl Acad Sci U S A
A balance between vector survival and virus transmission is achieved through JAK/STAT signaling inhibition by a plant virus. [Abstract]2022 Oct 11;119(41):e2122099119. PMID: 36191206 -
Cell Commun Signal
The protective effects of pericyte-derived microvesicles on vascular endothelial functions via CTGF delivery in sepsis. [Abstract]2021 Nov 16;19(1):115. PMID: 34784912 -
Phytomedicine
Wogonin ameliorates osteoarthritis by targeting the STAT3/PIM1 axis to attenuate chondrocyte senescence. [Abstract]2026 Apr:153:157986. PMID: 41722125 -
Phytomedicine
Eriocalyxin B induces ferroptosis through SIRT3 inhibition in triple-negative breast cancer. [Abstract]2025 Sep 11:148:157257. PMID: 40976126 -
Phytomedicine
Epigallocatechin gallate suppresses mitotic clonal expansion and adipogenic differentiation of preadipocytes through impeding JAK2/STAT3-mediated transcriptional cascades. [Abstract]2024 Jul:129:155563. PMID: 38552377 -
Phytomedicine
2023 Jun:114:154799. PMID: 37058945 -
Phytomedicine
Xuanfei Baidu Decoction suppresses complement overactivation and ameliorates IgG immune complex-induced acute lung injury by inhibiting JAK2/STAT3/SOCS3 and NF-κB signaling pathway. [Abstract]2023 Jan:109:154551. PMID: 36610119 -
Free Radic Biol Med
Mechanism of cigarette smoke in promoting small airway remodeling in mice via STAT 3 / PINK 1-Parkin / EMT. [Abstract]2024 Aug 28:S0891-5849(24)00630-0. PMID: 39214258 -
J Transl Med
VISTA expressed on tumor cells is regulated by m6A and influences immune microenvironment through STAT3/CCL22 in NSCLC. [Abstract]2025 Oct 2;23(1):1043. PMID: 41039458
Colivelin purchased from MedChemExpress. Usage Cited in: J Transl Med. 2025 Oct 2;23(1):1043. [Abstract]
Mice in the sti-STAT3 group were given Colivelin (1 mg/kg) via intraperitoneal injection daily. The left panel showed that VISTA overexpression and Colivelin injection (sti-STAT3, 1 mg/kg/day) affected tumor growth in C57BL/6 J mice. The right panel showed tumor volumes measured by growth curve every three days from day 7 to day 16 after cell transplantation.
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J Transl Med
Siramesine induced cell death of glioblastoma through inactivating the STAT3-MGMT signaling pathway. [Abstract]2025 Jul 10;23(1):780. PMID: 40640878 -
J Transl Med
Saliva-derived extracellular vesicles: a promising therapeutic approach for salivary gland fibrosis. [Abstract]2025 May 27;23(1):593. PMID: 40426212 -
J Transl Med
PD-1 regulates the anti-tumor immune function of macrophages through JAK2-STAT3 signaling pathway in colorectal cancer tumor microenvironment. [Abstract]2025 May 2;23(1):502. PMID: 40317043 -
Biomed Pharmacother
Water extract of sporoderm-broken spores of Ganoderma lucidum enhanced pd-l1 antibody efficiency through downregulation and relieved complications of pd-l1 monoclonal antibody. [Abstract]2020 Nov;131:110541. PMID: 33152901 -
Chin Med J (Engl)
Sphingosine-1-phosphate induces pulmonary artery smooth muscle cell proliferation, migration and pulmonary arterial remodeling by modulating sonic hedgehog signaling effector FoxM1. [Abstract]2026 May 5;139(9):1375-1387. PMID: 41859863 -
Oncogene
Activation of tumor suppressor LKB1 by honokiol abrogates cancer stem-like phenotype in breast cancer via inhibition of oncogenic Stat3. [Abstract]2017 Oct 12;36(41):5709-5721. PMID: 28581518 -
Stem Cell Res Ther
Modulation of senescent Lepr+ skeletal stem cells via suppression of leptin-induced STAT3‒FGF7 axis activation alleviates abnormal subchondral bone remodeling and osteoarthritis progression. [Abstract]2025 May 5;16(1):227. PMID: 40325465 -
Int J Nanomedicine
Mitigation of Sepsis-Induced Acute Lung Injury by BMSC-Derived Exosomal miR-125b-5p Through STAT3-Mediated Suppression of Macrophage Pyroptosis. [Abstract]2023 Nov 29:18:7095-7113. PMID: 38050472 -
Phytother Res
Dehydrocorydaline Promotes STAT3/Bcl-2 Axis-Mediated Macrophage Efferocytosis to Attenuate Apoptosis in Atherosclerotic Plaques. [Abstract]2026 May;40(5):2473-2490. PMID: 41699991 -
J Agric Food Chem
MIOX Aggravated DEHP-Induced Ferroptosis in Chicken Hepatocytes by Targeting STAT3 Phosphorylation. [Abstract]2025 Oct 22;73(42):27025-27037. PMID: 41070917 -
J Agric Food Chem
Indole-3-Propionic Acid Attenuates Neuroinflammation and Cognitive Deficits by Inhibiting the RAGE-JAK2-STAT3 Signaling Pathway. [Abstract]2025 Mar 5;73(9):5208-5222. PMID: 39992888 -
J Agric Food Chem
Promotion Effect of EGCG on the Raised Expression of IL-23 through the Signaling of STAT3-BATF2-c-JUN/ATF2. [Abstract]2021 Jul 21;69(28):7898-7909. PMID: 34227806 -
Ecotoxicol Environ Saf
Pyridaben inhibits cell cycle progression and delays early embryonic development in zebrafish (Danio rerio). [Abstract]2024 Aug 12:283:116857. PMID: 39137465 -
J Ethnopharmacol
Qizhiweitong granule alleviates diarrhea-predominant irritable bowel syndrome via inhibition of the IL-6/Src/STAT3 feedback loop. [Abstract]2025 Oct 22:120772. PMID: 41135620 -
J Ethnopharmacol
Network pharmacology and phytochemical composition combined with validation in vivo and in vitro reveal the mechanism of platycodonis radix ameliorating PM2.5-induced acute lung injury. [Abstract]2024 Sep 13:118829. PMID: 39278295 -
Commun Biol
Macrophages regulate vascular smooth muscle cell function during atherosclerosis progression through IL-1β/STAT3 signaling. [Abstract]2022 Dec 1;5(1):1316. PMID: 36456628 -
Cancer Immunol Immunother
Myeloid-derived suppressor cells cross-talk with B10 cells by BAFF/BAFF-R pathway to promote immunosuppression in cervical cancer. [Abstract]2022 Jun 20. PMID: 35725835 -
CNS Neurosci Ther
ShenQi DiHuang Decoction (SQDHD) Ameliorates Neuroinflammation and Neuropsychiatric Manifestations in Pristane Induced Lupus Mice via Blocking JAK1-STAT3 Pathway. [Abstract]2026 Mar;32(3):e70814. PMID: 41795136 -
Inflammation
AMPK Regulates M1 Macrophage Polarization through the JAK2/STAT3 Signaling Pathway to Attenuate Airway Inflammation in Obesity-Related Asthma. [Abstract]2025 Feb;48(1):372-392. PMID: 38886294 -
CNS Neurosci Ther
Circular RNA PTP4A2 regulates microglial polarization through STAT3 to promote neuroinflammation in ischemic stroke. [Abstract]2024 Apr;30(4):e14512. PMID: 37869777 -
Int J Mol Sci
Inhibition of PRMT1 Suppresses the Growth of U87MG-Derived Glioblastoma Stem Cells by Blocking the STAT3 Signaling Pathway. [Abstract]2024 Mar 3;25(5):2950. PMID: 38474197 -
Invest Ophthalmol Vis Sci
Effect of Dipyridamole on Experimental Autoimmune Uveitis: Reprogrammed Immune Cell Landscape and Reduced Th17 Pathogenicity. [Abstract]2025 Dec 1;66(15):16. PMID: 41334959 -
Int Immunopharmacol
NLRP3 regulates ferroptosis via the JAK2/STAT3 pathway in asthma inflammation: Insights from in vivo and in vitro studies. [Abstract]2024 Oct 18;143(Pt 2):113416. PMID: 39426227 -
Int Immunopharmacol
Small extracellular vesicles derived from human mesenchymal stem cells prevent Th17-dominant neutrophilic airway inflammation via immunoregulation on Th17 cells. [Abstract]2024 May 30:133:112126. PMID: 38669946 -
Inflamm Bowel Dis
2023 Dec 5;29(12):1929-1940. PMID: 37335900 -
J Ovarian Res
Obacunone alleviated the development of polycystic ovary syndrome via inhibiting STAT3 phosphorylation. [Abstract]2025 Dec 26;19(1):29. PMID: 41454293 -
Biochim Biophys Acta Mol Basis Dis
TAX1BP1 downregulation by STAT3 in cardiac fibroblasts contributes to diabetes-induced heart failure with preserved ejection fraction. [Abstract]2024 Feb;1870(2):166979. PMID: 38065272 -
Drug Dev Res
Knockdown of IGF2BP3 inhibits the tumorigenesis of gallbladder cancer and modifies tumor microenvironment. [Abstract]2022 Dec;83(8):1831-1844. PMID: 36184877 -
J Inflamm Res
SMP30 Attenuates Lens Epithelial Cells Pyroptosis of Cataract via the Downregulation of p-STAT3. [Abstract]2025 Sep 8:18:12361-12377. PMID: 40951443 -
J Inflamm Res
Tfh Exosomes Derived from Allergic Rhinitis Promote DC Maturation Through miR-142-5p/CDK5/STAT3 Pathway. [Abstract]2022 May 31:15:3187-3205. PMID: 35668915 -
Antiviral Res
2022 Jan:197:105228. PMID: 34929248 -
Front Mol Biosci
RIPK4 Suppresses the Invasion and Metastasis of Hepatocellular Carcinoma by Inhibiting the Phosphorylation of STAT3. [Abstract]2021 Jun 18:8:654766. PMID: 34222329 -
Sci Rep
An integrated bioinformatic investigation of succinic acid metabolism related genes in ccRCC followed by preliminary validation of SLC25A4 in tumorigenesis. [Abstract]2025 Jun 5;15(1):19736. PMID: 40473684 -
Sci Rep
Bone mesenchymal stem cells based on matric hydrogels attenuate intervertebral disc degeneration by suppressing oxidative stress-induced ferroptosis. [Abstract]2025 May 2;15(1):15378. PMID: 40316606 -
Oncol Rep
Butyrate increases methylglyoxal production through regulation of the JAK2/Stat3/Nrf2/Glo1 pathway in castration‑resistant prostate cancer cells. [Abstract]2024 May;51(5):71. PMID: 38577936 -
Aging
Overexpression of miR-142-5p inhibits the progression of nonalcoholic steatohepatitis by targeting TSLP and inhibiting JAK-STAT signaling pathway. [Abstract]2020 May 15;12(10):9066-9084. PMID: 32413869
Colivelin purchased from MedChemExpress. Usage Cited in: Aging. 2020 May 15;12(10):9066-9084. [Abstract]
The protein expression of the biomarkers of JAK-STAT signaling pathway. The expression of TNF-α, IFN-β, IL-6 and MCP-1 is all upregulated and IL-4 expression are downregulated in the group treated with miR-142-5p versus the NC group, and it could be rescued by Colivelin.
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Neurochem Res
Sphingosine-1-Phosphate Receptor 3 Mediated Neuroinflammation is Critically Involved in the Development of Brain Injury Following Cardiac Arrest in Mice. [Abstract]2026 Mar 19;51(2):112. PMID: 41851363 -
Cell Signal
Oncogenic role of PLOD3 mediated by SOX9 through IL-6/JAK/STAT3 pathway in cervical cancer. [Abstract]2026 Feb:138:112250. PMID: 41242365 -
Brain Res Bull
Electroacupuncture suppresses NK cell infiltration and activation in the ischemic mouse brain through STAT3 inhibition. [Abstract]2024 Nov 13:219:111128. PMID: 39542049 -
Cell Signal
Upregulation of HSP72 attenuates tendon adhesion by regulating fibroblast proliferation and collagen production via blockade of the STAT3 signaling pathway. [Abstract]2020 Jul;71:109606. PMID: 32199935 -
World J Stem Cells
Effects of miR-214-5p and miR-21-5p in hypoxic endometrial epithelial-cell-derived exosomes on human umbilical cord mesenchymal stem cells. [Abstract]2024 Nov 26;16(11):906-925. PMID: 39619875 -
Vascul Pharmacol
Antithrombotic properties of Tafamidis: An additional protective effect for transthyretin amyloid cardiomyopathy patients. [Abstract]2024 Jul 17:107411. PMID: 39029855 -
Appl Biochem Biotechnol
Mechanistic Study of S100A8-mediated Ferroptosis in Vascular Dementia Through the JAK2/STAT3 Pathway. [Abstract]2026 Jan 15. PMID: 41538098 -
Funct Integr Genomics
MAZ-mediated LAMA5 transcription activation promotes gastric cancer progression through the STAT3 signaling. [Abstract]2025 Mar 12;25(1):59. PMID: 40072648 -
Mol Immunol
Liquiritigenin regulates JAK/STAT3 and NF-κB signaling pathways to reduce colonic damage and barrier dysfunction caused by a high-salt diet. [Abstract]2026 Feb:190:86-100. PMID: 41558083 -
Mol Immunol
Cigarette smoke-exposed microparticles released from T lymphocytes contribute to autophagy and apoptosis dysfunction in pulmonary microvascular endothelial cells. [Abstract]2025 May:181:9-17. PMID: 40048930 -
Burns
Asiatic acid inhibits keloid fibroblast migration and collagen deposition via suppression of STAT3 activation. [Abstract]2025 Jun 23;51(8):107586. PMID: 40700781 -
Mol Biol Rep
Corosolic acid enhances oxidative stress-induced apoptosis and senescence in pancreatic cancer cells by inhibiting the JAK2/STAT3 pathway. [Abstract]2024 Jan 22;51(1):176. PMID: 38252208 -
Iran J Basic Med Sci
Dapagliflozin improves diabetic cardiomyopathy by suppressing the STAT3-YY1 signaling axis in cardiac fibroblasts. [Abstract]2025;28(11):1563-1574. PMID: 41170186 -
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Tissue Cell
Exosomes secreted from M2-polarized macrophages inhibit osteoclast differentiation via CYLD. [Abstract]2024 Nov 30:93:102645. PMID: 39671756 -
J Nat Med
Polydatin induces apoptosis and autophagy via STAT3 signaling in human osteosarcoma MG-63 cells. [Abstract]2020 Jun;74(3):533-544. PMID: 32222939 -
PeerJ
Ac2-26 attenuates hepatic ischemia-reperfusion injury in mice via regulating IL-22/IL-22R1/STAT3 signaling. [Abstract]2022 Sep 28;10:e14086. PMID: 36193422 -
BMC Neurosci
Esketamine attenuates traumatic brain injury by modulating STAT3-mediated Glycolysis and immune responses. [Abstract]2025 Mar 7;26(1):21. PMID: 40055623 -
Exp Ther Med
Glaucocalyxin A alleviates lipopolysaccharide-induced inflammation and apoptosis in pulmonary microvascular endothelial cells and permeability injury by inhibiting STAT3 signaling. [Abstract]2022 Apr;23(4):313. PMID: 35369532 -
Biomol Biomed
Salidroside exerts anti-tumor effects in ovarian cancer by inhibiting STAT3/c-Myc pathway-mediated glycolysis. [Abstract]2024 Dec 11;25(1):82-93. PMID: 39097833 -
Adv Rheumatol
Hck promotes IL-1β-induced extracellular matrix degradation, inflammation, and apoptosis in osteoarthritis via activation of the JAK-STAT3 signaling pathway. [Abstract]2024 Dec 18;64(1):88. PMID: 39696562 -
Biochem Cell Biol
HSPB8 facilitates prostate cancer progression via activating JAK/STAT3 signaling pathway. [Abstract]2023 Feb 1;101(1):1-11. PMID: 36318825 -
Biochem Cell Biol
NCAPG2 contributes to progression of malignant melanoma through regulating proliferation and metastasis. [Abstract]2022 Dec 1;100(6):473-484. PMID: 36265182 -
J Surg Res
Sildenafil Attenuates Persistent Pulmonary Hypertension of the Newborn via Inhibiting the Growth and Migration of Pulmonary Artery Smooth Muscle Cells. [Abstract]2025 Jan 13:306:249-256. PMID: 39809035 -
Int J Neurosci
MFG-E8 alleviates oxygen-glucose deprivation-induced neuronal cell apoptosis by STAT3 regulating the selective polarization of microglia. [Abstract]2021 Jan;131(1):15-24. PMID: 32098538 -
Pol J Pathol
miR-21 regulates LPS-induced apoptosis and inflammatory injury in rat cardiomyocytes by targeting PLD1 and STAT3. [Abstract]2025;76(2):131-140. PMID: 40977551 -
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J Physiol Investig
Tripartite Motif-containing Protein 11 Silencing Inhibits Proliferation and Glycolysis and Promotes Apoptosis of Esophageal Squamous Cell Carcinoma Cells by Inactivating Signal Transduction and Activation of Transcription Factor 3/c-Myc Signaling. [Abstract]2024 Jan 1;67(1):37-46. PMID: 38780271 -
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Ann Transl Med
Stromal cells promote chemoresistance of acute myeloid leukemia cells via activation of the IL-6/STAT3/OXPHOS axis. [Abstract]2020 Nov;8(21):1346. PMID: 33313091 -
Solvent & Solubility
DMSO : 66.67 mg/mL (25.21 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL. * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (287 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Chiba T, et al. Development of a femtomolar-acting humanin derivative named colivelin by attaching activity-dependent neurotrophic factor to its N terminus: characterization of colivelin-mediated neuroprotection against Alzheimer's disease-relevant insults in vitro and in vivo. J Neurosci. 2005 Nov 2;25(44):10252-61. [Content Brief]
[2]. Pan Z, et al. Upregulation of HSP72 attenuates tendon adhesion by regulating fibroblast proliferation and collagen production via blockade of the STAT3 signaling pathway.Cell Signal. 2020 Mar 18:109606. [Content Brief]
[3]. Zhao H, et al. Colivelin Rescues Ischemic Neuron and Axons Involving JAK/STAT3 Signaling Pathway.Neuroscience. 2019 Sep 15;416:198-206. [Content Brief]
[4]. Fang YY, et al. MFG-E8 alleviates oxygen-glucose deprivation-induced neuronal cell apoptosis by STAT3 regulating the selective polarization of microglia. Int J Neurosci. 2020 Mar 12:1-10. [Content Brief]
[5]. Chiu WC, et al. The Synthetic β-Nitrostyrene Derivative CYT-Rx20 Inhibits Esophageal Tumor Growth and Metastasis via PI3K/AKT and STAT3 Pathways. PLoS One. 2016 Nov 22;11(11):e0166453. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 0.3781 mL | 1.8903 mL | 3.7806 mL | 9.4514 mL |
| 5 mM | 0.0756 mL | 0.3781 mL | 0.7561 mL | 1.8903 mL | |
| 10 mM | 0.0378 mL | 0.1890 mL | 0.3781 mL | 0.9451 mL | |
| 15 mM | 0.0252 mL | 0.1260 mL | 0.2520 mL | 0.6301 mL | |
| 20 mM | 0.0189 mL | 0.0945 mL | 0.1890 mL | 0.4726 mL | |
| 25 mM | 0.0151 mL | 0.0756 mL | 0.1512 mL | 0.3781 mL |
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